Chau-Hwang Lee 李超煌
Research Fellow

Ways to contact me：

E-mail:cleegate.sinica.edu.tw
Phone:886-2-27898000 ext 18 or 53
Fax: 886-2-27826680
Website:
Address: Research Center for Applied Sciences, Academia Sinica
128 Sec. 2, Academia Rd., Nankang, Taipei 11529, Taiwan
中央研究院應用科學研究中心
台北市11529南港區研究院路二段128號

Education：

Experience：

Research Fields：

  • Cell-cell and cell-microenvironment interactions.

  • Super resolution far-field optical microscopy.

  • Differential sectioning microscopy.

  • Mechanical and electrical characteristics of bio-membranes.

  • Laser-assisted micro/nano fabrication.

Recent Publications：

  1. T.-H. Hsu, Y.-L. Kao, W.-L. Lin, J.-L. Xiao, P.-L. Kuo, C.-W. Wu, W.-Y. Liao, and C.-H. Lee, "Migration speed of cancer cells influenced by macrophages and myofibroblasts co-cultured in a microfluidic chip," Integrative Biology 4, 177 (2012).

  2. H.-Y. Hsieh, J.-L. Xiao, C.-H. Lee, T.-W. Huang, C.-S. Yang, P.-C. Wang, and F.-G. Tseng, 2011, "Au-coated polystyrene nanoparticles with HAR nanocorrugations via surface carboxylation shielded anisotropic etching for significant SERS signal enhancement," Journal of Physical Chemistry C 115, 16258 (2011).

  3. S.-H. Pan, Y.-C. Chao, P.-F. Hung, H.-Y. Chen, S.-C. Yang, Y.-L. Chang, C.-T. Wu, C.-C. Chang, W.-L. Wang, W.-K. Chan, Y.-Y. Wu, T.-F. Che, L.-K. Wang, C.-Y. Lin, Y.-C. Lee, M.-L. Kuo, C.-H. Lee, J. J. W. Chen, T.-M. Hong, and P.-C. Yang, "The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1," Journal of Clinical Investigation 121, 3189 (2011).

  4. T.-H. Liu, J.-L. Xiao, C.-H. Lee, and J.-Y. Lin, "Measurement of membrane rigidity on trapped unilamellar phospholipid vesicles by using differential confocal microscopy," Applied Optics 50, 3311 (2011).

  5. F.-C. Tsai, L.-A. Tai, Y.-J. Wang, J.-L. Xiao, T.-H. Hsu, C.-S. Yang, and C.-H. Lee, "Three-dimensional tracking and temporal analysis of liposomal transport in live cells using bright-field imaging," Microscopy Research and Technique 74, 531 (2011).

  6. T.-H. Hsu, J.-L. Xiao, Y.-W. Tsao, Y.-L. Kao, S.-H. Huang, W.-Y. Liao, and C.-H. Lee, "Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip," Lab on a Chip 11, 1808 (2011).

  7. C.-C. Wang, Y.-C. Kao, P.-Y. Chi, C.-W. Huang, J.-Y. Lin, C.-F. Chou, J.-Y. Cheng, and C.-H. Lee, "Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip," Lab on a Chip 11, 695 (2011).

  8. J.-L. Xiao, T.-H. Hsu, P.-Y. Hsu, W.-J. Yang, P.-L. Kuo, and C.-H. Lee, "Motion of cancer-cell lamellipodia perturbed by laser light of two wavelengths," Applied Physics Letters, 97, 203702 (2010).

  9. Chien-Hong Chen, Feng-Ching Tsai, Chun-Chieh Wang, and Chau-Hwang Lee, "Three-dimensional characterization of active membrane waves on living cells," Physical Review Letters 103, 238101 (2009).

  10. Chun-Chieh Wang, Chia-Pin Liang, and Chau-Hwang Lee, "Three-dimensional nanoparticle tracking and simultaneously membrane profiling during endocytosis of living cells," Applied Physics Letters 95, 203702 (2009).

  11. Chun-Chieh Wang, Kuang-Li Lee, and Chau-Hwang Lee, "Wide-field optical nano-profilometry using structured illumination," Optics Letters 34, 3538 (2009).

  12. T.-H. Hsu, M.-H. Yen, W.-Y. Liao, J.-Y. Cheng, and C.-H. Lee, "Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip," Lab on a Chip 9, 884 (2009).

  13. Jiunn-Yuan Lin, Ru-Ping Huang, Pei-Shui Tsai, and Chau-Hwang Lee, "Wide-field super-resolution optical sectioning microscopy using a single spatial light modulator," Journal of Optics A: Pure and Applied Optics 11, 015301 (2009).

  14. Chun-Chieh Wang, Hung-Jhang Jian, Chih-Wei Wu, and Chau-Hwang Lee, "Cell membrane deformations under magnetic force modulation characterized by optical tracking and non-interferometric wide-field profilometry," Microscopy Research and Technique 71, 594 (2008).

  15. C.-C. Wang, C.-W. Lee, C.-Y. Huang, J.-Y. Lin, P.-K. Wei, and C.-H. Lee, "Internalization of nanoparticles on cell membranes observed by non-interferometric wide-field optical profilometry," Applied Optics 47, 2458 (2008).

  16. Yu-Fen Chang, Qiong-Ru Chou, Jiunn-Yuan Lin, and Chau-Hwang Lee, "Fabrication of high-aspect-ratio silicon nanopillar arrays with the conventional reactive ion etching technique," Applied Physics A 86, 193 (2007).

  17. Chun-Chieh Wang, Jiunn-Yuan Lin, Hung-Jhang Jian, and Chau-Hwang Lee, "Transparent thin-film characterization by using differential optical sectioning interference microscopy," Applied Optics 46, 7460 (2007).

  18. T.-H. Hsu, W.-Y. Liao, P.-C. Yang, C.-C. Wang, J.-L. Xiao, and C.-H. Lee, "Dynamics of cancer cell filopodia characterized by super-resolution bright-field optical microscopy," Optics Express 15, 76 (2007).

Patents：

  1. Optical Profilometry. ROC (Taiwan) and US Patent pending

  2. Optical Sectioning Microcopy, US Patent 8,019,136 B2, ROC (Taiwan) Patent pending.

  3. Modulation Differential Confocal Microscopy, ROC (Taiwan) Patent I329207, US Patent pending.

  4. Method for Characterizing Transparent Thin-films Using Differential Optical Sectioning Interference Microscopy, US Patent 7,545,510, ROC (Taiwan) Patent I328676.

  5. Differential Confocal Microscopy, ROC (Taiwan) Patent 082212, US Patent 5,804,813.