Jung-Hsin Lin 林榮信
Assistant Research Fellow

Ways to contact me.....

My website

E-mail: jhlingate.sinica.edu.tw
Phone: 886-2-27898000 ext 63
Fax: 886-2-27826680
Address: Research Center for Applied Sciences, Academia Sinica 128 Sec. 2, Academia Rd., Nankang, Taipei 11529, Taiwan              中央研究院應用科學研究中心 台北市11529南港區研究院路二段128號

Education：

• Ph.D. in Biophysics, University of Duisburg, Germany (2000)

Experience：

• Assistant Professor, National Taiwan University (2003.2-)

• Joint Assistant Research Fellow, Institute of Biomedical Sciences, Academia Sinica (2004.2-)

• Bioinformatics Specialist, University of California at San Diego (2000.9-2002.8)

• Postdoctoral Research Associate, John von Neuman Institute for Computing, Forschungszentrum Jülich,
  Germany (2000.1-2000.9)

• Visiting Scholar, Computing Center, Academia Sinica (2002.12-2003.1)

• Visiting Scholar, Institute for Bioinformation Processing-2, Forschungszentrum Jülich, Germany (2002.9-2002.11)

Research Fields：

• Pharmacoinformatics
• Computational Biophysics
• Bioinformatics
• Structural Biology
• Molecular Simulations

Recent Publication：

1. A. L. Perryman, J.-H. Lin, J.A. McCammon.Restrained molecular dynamics of HIV-1 protease: Validating a
   new target for drug design. Biopolymer 82: 272-284 (2006)

2. A. L. Perryman, J.-H. Lin, J.A. McCammon. Optimization and computational evaluation of a series of
   potential active site inhibitors of the V82F/I84V drug-resistant mutant of HIV-1 protease: an application of
   the relaxed complex method of structural based drug design Chem. Biol. Drug Design. 67: 336-345 (2006).

3. D. T.-H. Chang, Y.-Z. Weng, J.-H. Lin, M.-J. Hwang, Y.-J. Oyang. Protemot: prediction of protein binding
   sites with automatically extracted geometrical templates Nucleic Acids Res. (accepted for publication in July,
   2006).

4. D. Vigil, J.-H. Lin, C. A. Sotriffer, J. K. Pennypacker, J.A. McCammon and S. S. Taylor. A simple electrostatic
   switch important in the activation of type I protein kinase A by cyclic AMP Prot. Sci. 15: 113-121 (2006).

5. J. R. Giorgione, J.-H. Lin, J.A. McCammon and A. C. Newton. Increased membrane affinity of the C1 domain
   of protein kinase Cδ components for the lack of involvement of its C2 Domain in membrane recruitment. J.
   Biol. Chem. 281: 1660-1669 (2006).

6. D. T.-H. Chang, Y.-J. Oyang, J.-H. Lin. MEDock: a web server for efficient prediction of ligand binding
   sites based on a novel optimization algorithm Nucleic Acids Res. 33: W233-W238 (2005) .

7. A. L. Perryman, J.-H. Lin, J.A. McCammon. HIV-1 protease molecular dynamics of a wild-type and of the
   V82F/I84V mutant: Possible contributions to drug resistance and a potential new drug target site for drugs
   Prot. Sci. 13: 1108-1123 (2004).

8. J.-H Lin, A. L. Perryman, J. R. Schames and J. A. McCammom. The relaxed complex method:
   Accommodating receptor flexibility for drug design with an improved scoring scheme Biopolymers 68: 47-62
   (2003).

9. J.-H Lin, N. A. Baker and J. A. McCammom. Bridging implicit and explicit solvent approaches for
   membrane electrostatics Biophys. J. 83: 1374-1379 (2002).

10. J.-H Lin, A. L. Perryman, J. R. Schames and J. A. McCammom. Computational drug design acommodating
    receptor flexibility: The relaxed complex scheme J. Am. Chem. Soc. 124: 5632-5633 (2002).

11. J.-H. Lin, and A. Baumgaertner. Stability of a melittin pore in a lipid bilayer : a molecular dynamics study.
    Biophys. J. 78: 1714-1724 (2000).

12. J.-H. Lin, and A. Baumgaertner. Molecular dynamics simulations of hydrophobic and amphiphatic proteins
    interacting with a lipid bilayer membrane. Comput.Theor.Poly.Sci. 10:1-2 97-102 (2000).

13. J.-H. Lin, and A. Baumgaertner. Adsorption of melittin to a lipid bilayer : a molecular dynamics study. J.Mol.
    Liquids 84:1 89-98 (2000).

Jung-Hsin Lin 林榮信
Assistant Research Fellow