Pei-Kuen Wei 魏培坤
Associate Director

Ways to contact me:

E-mail:pkweigate.sinica.edu.tw
Phone:886-2-2787-3146
Fax: 886-2-2787-3122
Address: Research Center for Applied Sciences, Academia Sinica
No. 128 Sec. 2, Academia Rd., Nankang, Taipei 11529, Taiwan
中央研究院應用科學研究中心
台北市11529南港區研究院路二段128號

Education:

Experience:

Research Fields:

  • Research Fields
    (1) Near-Field Optics, Nano-Photonics and Related Techniques
    (2) Applications of Nanostructures in Biosensing, Bioimaging and Green-Energy Devices.

    Recent Research Topics:
    (1) Nano-Optical Microscopy and Lithography:
    Our group is devoted to developing super-resolution optical techniques by using near-field optics. We developed various kinds of near-field microscopes to study different important thin-film devices, such as organic/inorganic thin films for light emitting devices, metallic/transparent nanostructures for biosensing and lithography, and dielectric/plasmonic structures for integrated optics. All these near-field measurements were done by the home-build systems. We have several patents for the nano-probe fabrication and system (US/TW patents). More than 30 papers relate to the near-field optical measurement have published. We also applied the concept of super-resolution optics for photomask nanolithography. This technology is more suitable for mass-production and commercial use. We invented near-field lithographic methods by using near-field focusing effects in mesoscale structures. The resolution is smaller than /5 (Optics Letters, 32, 71-73 (2007), the aspect ratio of focusing profiles is high (App. Phys. Lett. 88, 10110 (2006); Opt. Lett. 34, 1867-1869 (2009)). We can make photonic bandgap patterns with any designed defects by a simple photolithographic process (Nanotechnology 17, 1333 (2006)). This method can also be applied for making 3D subwavelength structures (Optical Express 15, 677 (2007)).

    (2) Nano-Photonic Devices:
    (a) Nano-Biosensors: We first confirmed the propagation of gap plasmon in nanoslits using the combinational studies of near-field microscopy and FDTD method. This work was introduced by Photonics Spectra. The gap plasmon is resonant in the nanoslit cavity. It results in extraordinary transmissions of TM polarized light. We studied the sensing applications of surface plasmon mode and gap plasmon mode in periodic gold nanoslits (J. Biomedical Optics, 12(4), 044023 (2007)). The biosensor using gap plasmon resonance has a sensitivity one order of magnitude higher than that of the surface plasmon resonance (Biosensor and Bioelectronics 24, 210 (2008)). The gap plasmon-based sensors are especially useful for high-throughput detections and biochip-based devices. We successfully demonstrated microarray detections for real-time measurements of antigen-antibody and DNA-DNA interactions (Opt. Express 17, 23104 (2009); Small 6, 1900 (2010); Plasmonics (2011)). In addition to the gap plasmon sensor, we also developed nano-fiber based sensors (J. Biomedical Optics, 2006, 11, 014032). We successfully applied the nano-fiber to measure the refractive index in cytoplasm of living cells (Appl. Phys. Lett. 93, 173110 (2008)) and pH values (Opt. Lett., 35, 944 (2010)).
    (b) Green Energy Devices: We improved the efficiencies of light emitting devices/solar cells by using nanostructures. For conventional OLEDs, twice brightness enhancement was achieved by using the surface plasmon effects of gold nanowire arrays (Appl. Phys. Lett. 92, 013303 (2008)).The metallic nanostructures can also be used as transparent electrodes (Organ. Electron.12, 2011) for OLEDs and organic solar cells. Recently, we developed a more efficient and cost-effective way to enhance the light extraction by using antireflection effect of transparent nanopillars (Opt. Express, 19. A295 (2011), selected paper 1). We also developed some optical novel components by using extraordinary optical properties of nanostructures, such as giant birefringence in metallic nanoslit which can be used as ultra-thin wavelength plates (Appl. Phys. Lett. 95, 013105 (2009)).
  • Honors and Awards:
    1994 Doctoral Thesis Award, Optical Society of Taiwan
    1996, 1998 Distinguished Postdoctoral Scholars, Academia Sinica
    Publications selected as 2007 and 2009 Academia Sinica significant researches
    Students awards(main advisor)
    Wei-Lun Cheng, 2005 Optics and Photonics in Taiwan, Student Paper Award
    Kuang-Li Lee, 2007 Optics and Photonics in Taiwan, Student Best Post Award
    Shen-Yu Hsu, 2008 SID International Conference, Student Travel Grant (US$500)
    Chia-Wei Lee, 2008 International Conference on Laser Applications in Life Sciences (LAIS), Student Paper Award
    En-Hong Lin, 2009 Optics and Photonics in Taiwan, Student Paper Award
    Su-Hann Wu, 2009 Optics and Photonics in Taiwan, Student Paper Award
    Yu-Hsuan Ho, 2011 SID International Conference, Student Travel Grant (US$500)
    Su-Hann Wu, 2011 Optics and Photonics in Taiwan, Student Paper Award

    News:
    1. Our research, “Giant Birefringence Induced by Plasmonic Nanoslit Arrays,” Appl. Phys. Lett. 95, 013105 (2009), was selected and reported in the Laser Focus World as one of the Accelerated Ingenuity in 2009.
    2. Our paper, "Size-Dependent Endocytosis of Gold Nanoparticles Studied by Three-Dimensional Mapping of Plasmonic Scattering Images" 2010, 8:33, J. Nanobiotechnology. (2010) was is a high access paper in Journal of Nanobiotechnology (Total accesses to this article since publication: 2197)
    3. Our paper, ”Sensitive Label-Free Biosensors by Using Gap Plasmons in Gold Nanoslits”, Biosensors and Bioelectronics 24, 210-215 (2008), was selected in the book “Chemical Sensors: Fundamental of Sensing Materials (2010)” with 2 pages introduction.
    4. The research, “Intensity sensitivity of gold nanostructures and its application for high-throughput biosensing,” Optics Express, 17 Issue 25, pp.23104-23113 (2009), was selected as significant research of Academia Sinica in 2010.
    5. The paper, ”Extraction enhancement in organic light emitting devices by using metallic nanowire arrays”, Appl. Phys. Lett. 92, 013303 (2008), was a top 20 download paper in Jan. issue (2008) of Appl. Phys. Lett. and was reported by the website (IOP), nanotechweb.org.
    6. The research, ”Two-Dimensional Refractive Index Profiling by Using Differential Near-Field Scanning Optical Microscopy”, Appl. Phys. Lett. 91, 061123 (2007), was introduced by the optical magazine, Photonics Spectra in 2010
    7. The research, “Fabrication of a close-packed hemispherical submicron lens array and its application in photolithography”, Optical Express, Vol. 15, Issue 11, pp. 6774-6783, (2007), was selected in significant researches of Academia Sinica (2007).
    8. The paper, ”Sensitive Biosensor Array by Using Surface Plasmon Resonance on Metallic NanoSlits”, J. Biomedical Optics, 12(4), 044023 (2007), was most a frequently downloaded paper in digital library and selected as top notch research in December, 2007.
    9. The paper, “Characterization and applications of single fluorescent nanodiamonds as cellular biomarkers” PNAS 104: 727-732 (2007), (collaborated with W. S. Fann in IAMS, academia sinica) was reported by news of Anal. Chem., 2007, 79, 1768.
    10. Many published papers were also selected by Virtual Journals such as Nanoscale Sciences and Technology and Biological Physics Research.

Recent Publications:

  1. Recent Publications (2007-2012)

    1. Kuang-Li Lee, Pei-Wen Chen, Shu-Han Wu, Jhih-Bin Huang, Sen-Yeu Yang, Pei-Kuen Wei*, "Enhancing Surface Plasmon Detection Using Template-Stripped Gold Nanoslit Arrays on Plastic Films", ACS Nano , Article ASAP, DOI: 10.1021/nn3001142 (2012)
    2. Rakesh Singh Moirangthem, Mohammad Tariq Yaseen, Pei-Kuen Wei, Ji-Yen Cheng, and Yia-Chung Chang, "Enhanced localized plasmonic detections using partially-embedded gold nanoparticles and ellipsometric measurements", Biomedical Optics Express, Vol. 3, Issue 5, pp. 899-910 (2012)
    3. Y. H. Ho, D. W. Huang, Y. T. Chang, Y. H. Yeh, C. W. Chu, W. C. Tian, C. T. Chen, and P. K. Wei*,“Improve efficiency of white organic light-emitting diodes by using nanosphere arrays in color conversion layers,“ Opt. Express 20, 3005-3014 (2012)
    4. Kuang-Li Lee, Shu-Han Wu, Chia-Wei Lee, and Pei-Kuen Wei*, "Sensitive biosensors using Fano resonance in single gold nanoslit with periodic grooves", Optics Express, Vol. 19, Issue 24, pp. 24530-24539 (2011)
    5. Kuang-Li Lee and Pei-Kuen Wei*," Optimization of Periodic Gold Nanostructures for Intensity-Sensitive Detection", Appl. Phys. Lett. 99, 083108 (2011)
    6. Rakesh Singh Moirangthem, Yia-Chung Chang* and Pei-Kuen Wei, "Ellipsometry study on gold-nanoparticle-coated gold thin film for biosensing application", Biomed. Opt. Express 2, No. 9 ,2569 (2011)
    7. Tzu-Yi Liao, Ba-Yan Lee, Chia-Wei Lee, Pei-Kuen Wei*," Large-area Raman Enhancement Substrates Using Spontaneous Dewetting of Gold Films and Silver Nanoparticles Deposition, " Sensors and Actuators B: Chemical, 156, 2011, Pages 245-250 (*corresponding author)
    8. Shen-Yu Hsu, Tai-Hsiang Jen, En-Hong Lin and Pei-Kuen Wei*, "Near-Field Coupling Method for Subwavelength Surface Plasmon Polariton Waveguides", Plasmonics 6, No. 3, 557-563 (2011) (*corresponding author)
    9. Kuang-Li Lee, Yi-Hsin Tai, and Pei-Kuen Wei* ,"Structure Effect on Sensitivity of Gold Nanoslits Studied by Spectral Integration Method", Plasmonics,, 6, No 3, 483-490 (2011) (*corresponding author)
    10. Ho Yu-Hsuan; Liu, Chung-Chun; Liu, Shun-Wei; Liang, Hsun; Chu, Chih-Wei; Wei, Pei-Kuen*, "Efficiency enhancement of flexible organic light-emitting devices by using antireflection nanopillars", Optics Express, Vol. 19 Issue S3, pp.A295-A302 (2011) (*corresponding author)
    11. Yu-Hsuan Ho, Kuan-Yu Chen, Shun-Wei Liu, Yung-Ting Chang, Ding-Wei Huang, Pei-Kuen Wei*,"Transparent and conductive metallic electrodes fabricated by using nanosphere lithography" Organic Electronics, Volume 12, Issue 6, June 2011, Pages 961-965(*corresponding author)
    12. Rakesh Singh Moirangthem, Yia-Chung Chang and Pei-Kuen Wei," Investigation of Surface Plasmon Biosensing using Gold Nanoparticles Enhanced Ellipsometry", Opt. Lett. Vol. 36, Issue 5, pp. 775-777 (2011)
    13. Wan-Shao Tsai, Sheng-Chieh Piao and Pei-Kuen Wei*,”Refractive index measurement of optical waveguides using modified end-fire coupling method” Opt. Lett. 36, 2008-2010 (2011)
    14. Chang, Wei-Yi, Wu, Jing-Tang, Lin, Kai-Heng, Yang, Sen-Yeu, Lee, Kuang-Li, Wei, Pei-Kuen," Fabrication of gold sub-wavelength pore array using gas-assisted hot embossing with anodic aluminum oxide (AAO) template", Microelectronic Engineering, ISSN: 0167-9317, Vol: 88, Issue: 6, Date: 2011-06-01, Start page: 909, pages: 5
    15. Chang, Wei-Yi, Lin, Kai-Heng, Wu, Jing-Tang, Yang, Sen-Yeu, Lee, Kuang-Li, Wei, Pei-Kuen, " Novel fabrication of an Au nanocone array on polycarbonate for high performance surface-enhanced Raman scattering," Journal of Micromechanics and Microengineering, ISSN: 0960-1317, Vol: 21, Issue: 3, Date: 2011-03-01, Start page: 035023,
    16. Sheng-Hann Wang, Chia-Wei Lee, Arthur Chiou and Pei-Kuen Wei*,"Size-Dependent Endocytosis of Gold Nanoparticles Studied by Three-Dimensional Mapping of Plasmonic Scattering Images" 2010, 8:33, J. Nanobiotechnology. (2010) (*corresponding author)
    17. Tzu-Hung Hsiao; Chien-Hong Lin; Te-Tsui Lee; Ji-Yen Cheng; Pei-Kuen Wei; Eric Y. Chuang; Konan Peck ,"Verifying expressed transcript variants by detecting and assembling stretches of consecutive exons", Nucleic Acids Research 2010, 38 ; e187
    18. Chen, Hung-Pin, Wen, Yu-Chieh, Chen, Yi-Hsin, Tsai, Cheng-Hua, Lee, Kuang-Li, Wei, Pei-Kuen, Sheu, Jinn-Kong,Sun, Chi-Kuang, "Femtosecond laser-ultrasonic investigation of plasmonic fields on the metal/gallium nitride interface", Applied Physics Letters, ISSN: 0003-6951, Vol: 97, Issue: 20, Date: 2010-11-15, page: 201102
    19. Kuang-Li Lee and Pei-Kuen Wei*, "Enhancing Surface Plasmon Detection Using Ultrasmall Nanoslits and Multispectral Integration Method," Small, Volume 6, Issue 17, September 6, 2010, Pages: 1900–1907 (*corresponding author)
    20. Wei, D.H.; Cheng, K.W.; Yao, Y.D.; Hsu, S.Y.; Wei, P.K.; Huang, J.H, "Color Variation in Periodic Ag Line Arrays Patterned by Using Electron-Beam Lithography," Journal of Nanoscience and Nanotechnology, 10, July 2010 , pp. 4581-4585(5)
    21. Rakesh Singh Moirangthem, Yia-Chung Chang, Shih-Hsin Hsu, Pei-Kuen Wei," Surface plasmon resonance ellipsometry based sensor for studying biomolecular interaction", Biosens. and Bioelectron 25 (12), p.2633-2638, Aug 2010
    22. Yi-Hsin Tai and Pei-Kuen Wei, "Sensitive Liquid Refractive Index Sensors using Tapered Optical Fiber Tips", Opt. Lett., 35 , 944-946 (2010) (*corresponding author)
    23. Shih-Hsin Hsu, Yia-Chung Chang,* Yi-Chun Chen, Pei-Kuen Wei, Y D Kim, “Optical metrology of randomly-distributed Au colloids on a multilayer film,” Optics Express, 18 Issue 2, pp.1310-1315 (2010)
    24. R. Thangavel, Rakesh Singh Moirangthem, Wei-Shan Lee, Yia-Chung Chang,∗ Pei-Kuen Wei and J. Kumare, “Cesium doped and undoped ZnO nanocrystalline thin films: a comparative study of structural andmicro-Raman investigation of optical phonons,” J. Raman Spectrosc. (2010) DOI 10.1002/jrs.2599.
    25. Kuang-Li Lee, Shu-Han Wu, Pei-Kuen Wei,* “Intensity sensitivity of gold nanostructures and its application for high-throughput biosensing,” Optics Express, 17 Issue 25, pp.23104-23113 (2009) (*corresponding author)
    26. Shen-Yu Hsu, Kuang-Li Lee, En-Hong Lin, Ming-Chang Lee, Pei-Kuen Wei*, “Giant Birefringence Induced by Plasmonic Nanoslit Arrays,” Appl. Phys. Lett. 95, 013105 (2009) (*corresponding author)
    27. Pei-Kuen Wei,* Wei-Lun Chang, Kunag-Li, Lee and En-Hong Lin, “Focusing Subwavelength Light by Using Nanoholes in a Transparent Thin Film,” Opt. Lett. 34, 1867-1869 (2009) (*corresponding author)
    28. Chia-Wei Lee, Miin Jang Chen, Ji-Yen Cheng and Pei-Kuen Wei*, “Morphological Studies of Living Cells Using Gold Nanoparticles and Dark-Field Optical Section Microscopy,” J. Biomedical Optics, 14(03), 034016 (2009) (*corresponding author)
    29. Po-Keng Lin, Keng-hui Lin, Chi-Cheng Fu, K.-C. Lee, Pei-Kuen Wei, Woei-Wu Pai, Pei-Hsi Tsao, Y.-L. Chen and W. S. Fann, ”The One-Dimensional Dynamics and Transport of DNA Molecules in a Quasi-Two-Dimensional Nanoslit," Macromolecules, 42, 1770-1774, 2009.
    30. Chia-Wei Lee, En-Hong Lin, Ji-Yen Cheng and Pei-Kuen Wei*, “Study of Gold Nanoparticles and Live Cells Interactions by Using Planar Evanescent Wave Excitation,” J. Biomed. Opt. 14, 021005 (2009) (*corresponding author)
    31. Jung-Yan Lee, Chia-Wei Lee, En-Hong Lin, and Pei-Kuen Wei*, “Single Live Cell Refractometer Using Nanoparticles Coated Fiber Tip”, Appl. Phys. Lett. 93 173110 (2008) (*corresponding author)
    32. Kuang-Li Lee, Way-Seen Wang and Pei-Kuen Wei*, “Comparisons of Surface Plasmon Sensitivities in Periodic Gold Nanostructures”, Plasmonics (10.1007/s11468-008-9065-z) Sept. (2008) (*corresponding author)
    33. Kuang-Li Lee, Way-Seen Wang and Pei-Kuen Wei*,”Sensitive Label-Free Biosensors by Using Gap Plasmons in Gold Nanoslits”, Biosensors and Bioelectronics 24, 210-215 (2008) (*corresponding author)
    34. Shen-Yu Hsu, Ming-Chang Lee, Kuang-Li Lee and Pei-Kuen Wei*,” Extraction enhancement in organic light emitting devices by using metallic nanowire arrays”, Appl. Phys. Lett. 92, 013303 (2008) (*corresponding author)
    35. Yia-Chung Chang, Shih-Hsin Hsu, Pei-Kuen Wei, and Young Dong Kim, “Optical nanometrology of Au nanoparticles on a multilayer film”, Phys. Stat. Sol. (c) 5, 1194–1197 (2008)
    36. Chun-Chieh Wang, Chia-Wei Lee, Chia-Yun Huang, Jiunn-Yuan Lin, Pei-Kuen Wei, and Chau-Hwang Lee, “Obervation of nanoparticle internalization on cellular membranes by using noninterferometric widefield optical profilometry”, Appl. Opt. 47, 2458 (2008)
    37. E. D. Fraser,C. H. Kim, S. Hegde, H. Zeng, H. Luo and P. K. Wei, “Magnetization reversal in epitaxial MnAs thin films,” J. Appl. Phys., 104, 033921 (2008)
    38. Wei-Lun Chang and Pei-Kuen Wei,* “Fabrication of a close-packed hemispherical submicron lens array and its application in photolithography”, Optical Express, Vol. 15, Issue 11, pp. 6774-6783, (2007) (*corresponding author)
    39. Wan-Shao Tsai, Way-Seen Wang and Pei-Kuen Wei*,”Two-Dimensional Refractive Index Profiling by Using Differential Near-Field Scanning Optical Microscopy”, Appl. Phys. Lett. 91, 061123 (2007) (*corresponding author)
    40. Kuang-Li Lee, Chia-Wei Lee, and Pei-Kuen Wei*,”Sensitive Detection of Nanoparticles using Metallic Nanoslit Arrays”, App. Phys. Lett. 90, 233119 (2007) (*corresponding author)
    41. Kun-Li Lee, Way-Seen Wang and Pei-Kuen Wei*,” Sensitive Biosensor Array by Using Surface Plasmon Resonance on Metallic NanoSlits”, J. Biomedical Optics, 12(4), 044023 (2007) (*corresponding author)
    42. T. Y. Lin, P. K. Wei, E. H. Lin, T. L. Tseng and R. Chang, “Investigation on the Correlation Between the Crystalline and Optical Properties of InGaN Using Near-Field Scanning Optical Microscopy”, Electrochemical and Solid-State Letters 10,217-219 (2007)
    43. Chi-Cheng Fu, Hsu-Yang Lee, Kowa Chen, Tsong-Shin Lim, Hsiao-Yun Wu, Po-Keng Lin, Pei-Kuen Wei, Pei-Hsi Tsao, Huan-Cheng Chang, and Wunshain Fann, “Characterization and applications of single fluorescent nanodiamonds as cellular biomarkers” PNAS 104: 727-732 (2007)
    44. Po-Keng Lin, Chi-Cheng Fu, Y.-L. Chen, Yan-Ru Chen, Pei-Kuen Wei, C. H. Kuan, and W. S. Fann,“ Static conformation and dynamics of single DNA molecules confined in nanoslits“ Phy. Rev. E, 75 (2007)
    45. F.-C. Chien , C.-Y. Lin, J.-N. Yih, K.-L. Lee, C.-W. Chang, P.-K. Wei, C.-C. Sun and S.-J. Chen,” Coupled waveguide-surface plasmon resonance biosensor with subwavelength grating”, Biosensors and Bioelectronics,22 (2007) 2737-2742
    46. Wei-Lun Chang, Pei-Hsi Tsao and Pei-Kuen Wei,* “Sub-100nm Photolithography by Using TE-Polarized Waves in Transparent Nano Structures” Optics Letters, 32, 71-73 (2007) (*corresponding author)

Patents:

  1. TW patent (26A-930728) “平面光學消逝波微型陣列讀取系統” Pei-Kuen Wei (2006,10~2025, 11)
  2. Pei-Kuen Wei, “Method and system for reading microarrays”, Publication Application No. US20060186346
  3. TW patent ”奈米光纖探測器”, Pei-Kuen Wei and Yi-Chun Chen, TW1246995, Jan. 11, 2006
  4. US patent “ Etching method for fabricating high quality optical fiber probe”, Pei-Kuen Wei and Yi-Chun Chen, US 6,905,627B2, Jun. 14, 2005
  5. US patent “Large Area Scanning Tip System For Near Field Microscope ”。Pei-Kuen Wei and Wun-shain Fann. Period: 2001,8~ 2018,12,No. US 6,271,513B1。
  6. Taiwan patent: “可進行大面積掃瞄之剪力回饋架構、利用此架構形成之近場光學顯微鏡”。發明人:魏培坤,范文祥。專利權人:行政院國家科學委員會, period:2000,7~ 2018,9,No:117513。