CH Lee's page

Awards and Publications:

Recent awards and honor to the group members:

   Dr. Chau-Hwang Lee, 2012 Junior Research Investigators Award, Academia Sinica, Taiwan.

   Yu-Chiu Kao, 2011 Excellent Master Thesis Award by the Chinese Physical Society R.O.C.

    Dr. Chau-Hwang Lee, 2010 Dr. Ta-You Wu Memorial Award, National Science Council, Taiwan.

  Dr. Chun-Chieh Wang, Third Place Poster Award in the 3rd International Symposium on Bio-Inspired Engineering (ISBIE 2009).

  Tsi-Hsuan Hsu, 2009 Excellent Paper Award for Ph.D. Students, National Yang-Ming University.

  Dr. Chun-Chieh Wang, 2009 Distinguished Postdoctoral Scholar of Academia Sinica.

  Tsi-Hsuan Hsu, 2007 Excellent Master Thesis Award by the Optical Engineering Society R.O.C.

 

Our paper about controlling the motion of cancer-cell lamellipodia by laser light is selected into the Research Highlights Archive of Applied Physics Letters.

Our paper about the characterization of active cell-membrane waves is reported by Physical Review Focus and Physicsworld.com (November 2009).

    

 

Most Frequently Cited Papers (>= 25 citations)

  1. C.-H. Lee and J. Wang, “Noninterferometric differential confocal microscopy with 2-nm depth resolution,” Optics Communications 135, 233 (1997).

  2. C.-H. Lee, W.-C. Lin, and J. Wang, “All-optical measurements of the bending rigidity of lipid-vesicle membranes across structural phase transitions,” Physical Review E 64, 020901(R) (2001).

  3. T.-Y. Chien, C.-L. Chang, C.-H. Lee, J.-Y. Lin, J. Wang, and S.-Y. Chen, “Spatially localized self-injection of electrons in a self-modulated laser wakefield accelerator by using a laser-induced transient density ramp,” Physical Review Letters 94, 115003 (2005).

  4. H.-H. Chu, S.-Y. Huang, L.-S. Yang, T.-Y. Chien, Y.-F. Xiao, J.-Y. Lin, C.-H. Lee, S.-Y. Chen, and J. Wang, “A versatile 10-TW laser system with robust passive controls to achieve high stability and spatiotemporal quality,” Applied Physics B 79, 193 (2004).

  5. C.-H. Lee, H.-Y. Mong, and W.-C. Lin, “Noninterferometric wide-field optical profilometry with nanometer depth resolution,” Optics Letters 27, 1773 (2002).

  6. C.-H. Lee, C.-L. Guo, and J. Wang, “Optical measurement of the viscoelastic and biochemical responses of living cells to mechanical perturbation,” Optics Letters 23, 307 (1998).

  7. C.-H. Pai, S.-Y. Huang, C.-C. Kuo, M.-W. Lin, J. Wang, S.-Y. Chen, C.-H. Lee, and J.-Y. Lin, “Fabrication of spatial transient-density structures as high-field plasma photonic devices,” Physics of Plasmas 12, 070707 (2005).

  8. Y.-F. Xiao, H.-H. Chu, H.-E. Tsai, C.-H. Lee, J.-Y. Lin, J. Wang, and S.-Y. Chen, “Efficient generation of extended plasma waveguides with the axicon ignitor-heater scheme,” Physics of Plasmas 11, L21 (2004).

 

                       The h-index of Dr. Chau-Hwang Lee's publications = 14.

 

 

 

Publications (PDF files of the reprints may be requested via e-mail.)

Cell activities in microenvironments

  • Journal Papers:

  1. J.-W. Huang, H.-J. Pan, W.-Y. Yao, Y.-W. Tsao, W.-Y. Liao, C.-W. Wu, Y.-C. Tung, and C.-H. Lee, “Interaction between lung cancer cell and myofibroblast influenced by cyclic tensile strain,” Lab on a Chip 13, 1114 (2013).

  2. J.-L. Xiao, H.-J. Pan, and C.-H. Lee, “Optically micropatterned culture of adherent cells,” Journal of Biomedical Optics 17, 075004 (2012).

  3. T.-H. Hsu, Y.-L. Kao, W.-L. Lin, J.-L. Xiao, P.-L. Kuo, C.-W. Wu, W.-Y. Liao, and C.-H. Lee, “Migration speed of cancer cells influenced by macrophages and myofibroblasts co-cultured in a microfluidic chip,” Integrative Biology 4, 177 (2012).

  4. T.-H. Hsu, J.-L. Xiao, Y.-W. Tsao, Y.-L. Kao, S.-H. Huang, W.-Y. Liao, and C.-H. Lee, “Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip,” Lab on a Chip 11, 1808 (2011).

  5. C.-C. Wang, Y.-C. Kao, P.-Y. Chi, C.-W. Huang, J.-Y. Lin, C.-F. Chou, J.-Y. Cheng, and C.-H. Lee, “Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip,” Lab on a Chip 11, 695 (2011).

  6. J.-L. Xiao, T.-H. Hsu, P.-Y. Hsu, W.-J. Yang, P.-L. Kuo, and C.-H. Lee, “Motion of cancer-cell lamellipodia perturbed by laser light of two wavelengths,” Applied Physics Letters 97, 203702 (2010).

 

  • International Conference Presentations:

  1. P.-Y. Chi, C.-H. Lee, and C.-F. Chou, “Study cell-cell communications across nano-passages,” 2012 Annual Meeting of the American Society for Cell Biology (San Francisco, California, USA), paper 1679.

  2. C.-H. Lee, J.-W. Huang, H.-J. Pan, W.-Y. Yao, Y.-W. Tsao, C.-W. Wu, W.-Y. Liao, and Y.-C. Tung, “Interaction between lung cancer cell and myofibroblast mediated by cyclic tensile strain,” 2012 Annual Meeting of the American Society for Cell Biology (San Francisco, California, USA), paper 1752.

  3. B. Patra, Y.-H. Chen, C.-C. Peng, C.-H. Lee, and Y.-C. Tung, “Microfluidic device for uniform-sized 3D cell spheroid formation and culture,” The 4th International Symposium on Microchemistry and Microsystems (Hsin-Chu, Taiwan), June 10–13, 2012, paper 99.

  4. C.-H. Lee, T.-H. Hsu, Y.-L. Kao, W.-L. Lin, J.-L. Xiao, P.-L. Kuo, C.-W. Wu, and W.-Y. Liao, “Interactions among cancer cells and stromal cells in multi-chamber chips,” The 4th International Symposium on Microchemistry and Microsystems (Hsin-Chu, Taiwan), June 10–13, 2012, paper 41.

  5. J.-L. Xiao, H.-J. Pan, and C.-H. Lee, “Micropatterned culture of adherent cancer cells by using light fences,” Focus on Microscopy 2012 (Singapore).

  6. C.-H. Lee, T.-H. Hsu, W.-L. Lin, Y.-L. Kao, and W.-Y. Liao, “Using a three-chamber culture chip to study the interactions among cancer cells and two types of stromal cells,” MicroTAS 2011 (Seattle, Washington, USA), paper 0731.

  7. J.-L. Xiao, T.-H. Hsu, P.-L. Kuo, and C.-H. Lee, “Controlling the movements of cancer-cell lamellipodia by laser light,” International Quantum Electronics Conference (IQEC)/Conference on Lasers and Electro-Optics (CLEO) Pacific Rim 2011 (Sydney, Australia), paper 280.

  8. C.-H. Lee, C.-C. Wang, Y.-C. Kao, P.-Y. Chi, C.-W. Huang, C.-F. Chou, and J.-Y. Cheng, “Asymmetric cancer-cell filopodium growth induced by electric fields in a microfluidic culture chip,” Second Conference on Advances in Microfluidics and Nanofluidics and Asian-Pacific International Symposium on Lab on Chip (Singapore), January 5–7, 2011.

  9. T.-H. Hsu, J.-L. Xiao, Y.-W. Tsao, Y.-L. Kao, S.-H. Huang, W.-Y. Liao, and C.-H. Lee, “Paracrine loops between cancer cells and fibroblasts in a microfluidic chip,” Second Conference on Advances in Microfluidics and Nanofluidics and Asian-Pacific International Symposium on Lab on Chip (Singapore), January 5–7, 2011.

 

Differential Confocal Microscopy, Wide-field Optical Profilometry, Super-resolution Bright-field Optical Microscopy, and their Applications in Biophysics and Cell Biology
  • Journal Papers:

  1. S.-H. Pan, Y.-C. Chao, P.-F. Hung, H.-Y. Chen, S.-C. Yang, Y.-L. Chang, C.-T. Wu, C.-C. Chang, W.-L. Wang, W.-K. Chan, Y.-Y. Wu, T.-F. Che, L.-K. Wang, C.-Y. Lin, Y.-C. Lee, M.-L. Kuo, C.-H. Lee, J. J. W. Chen, T.-M. Hong, and P.-C. Yang, “The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1,” Journal of Clinical Investigation 121, 3189 (2011).

  2. T.-H. Liu, J.-L. Xiao, C.-H. Lee, and J.-Y. Lin, “Measurement of membrane rigidity on trapped unilamellar phospholipid vesicles by using differential confocal microscopy,” Applied Optics 50, 3311 (2011).

  3. F.-C. Tsai, L.-A. Tai, Y.-J. Wang, J.-L. Xiao, T.-H. Hsu, C.-S. Yang, and C.-H. Lee, “Three-dimensional tracking and temporal analysis of liposomal transport in live cells using bright-field imaging,” Microscopy Research and Technique 74, 531 (2011).

  4. Chien-Hong Chen, Feng-Ching Tsai, Chun-Chieh Wang, and Chau-Hwang Lee, “Three-dimensional characterization of active membrane waves on living cells,” Physical Review Letters 103, 238101 (2009).

  5. Chun-Chieh Wang, Chia-Pin Liang, and Chau-Hwang Lee, “Three-dimensional nanoparticle tracking and simultaneously membrane profiling during endocytosis of living cells,” Applied Physics Letters 95, 203702 (2009).

  6. Chun-Chieh Wang, Kuang-Li Lee, and Chau-Hwang Lee, “Wide-field optical nano-profilometry using structured illumination,” Optics Letters 34, 3538 (2009).

  7. T.-H. Hsu, M.-H. Yen, W.-Y. Liao, J.-Y. Cheng, and C.-H. Lee, “Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip,” Lab on a Chip 9, 884 (2009).

  8. Jiunn-Yuan Lin, Ru-Ping Huang, Pei-Shui Tsai, and Chau-Hwang Lee, “Wide-field super-resolution optical sectioning microscopy using a single spatial light modulator,” Journal of Optics A: Pure and Applied Optics 11, 015301 (2009).

  9. Chun-Chieh Wang, Hung-Jhang Jian, Chih-Wei Wu, and Chau-Hwang Lee, “Cell membrane deformations under magnetic force modulation characterized by optical tracking and profilometry,” Microscopy Research and Technique 71, 594 (2008).

  10. C.-C. Wang, C.-W. Lee, C.-Y. Huang, J.-Y. Lin, P.-K. Wei, and C.-H. Lee, “Internalization of nanoparticles on cell membranes observed by non-interferometric wide-field optical profilometry,” Applied Optics 47, 2458 (2008).

  11. Chun-Chieh Wang, Jiunn-Yuan Lin, Hung-Jhang Jian, and Chau-Hwang Lee, “Transparent thin-film characterization by using differential optical sectioning interference microscopy,” Applied Optics 46, 7460 (2007).

  12. T.-H. Hsu, W.-Y. Liao, P.-C. Yang, C.-C. Wang, J.-L. Xiao, and C.-H. Lee, “Dynamics of cancer cell filopodia characterized by super-resolution bright-field optical microscopy,” Optics Express 15, 76 (2007).

  13. Chun-Chieh Wang, Jiunn-Yuan Lin, Hsiao-Chao Chen, and Chau-Hwang Lee, “Dynamics of cell membranes and the underlying cytoskeletons observed by non-interferometric wide-field optical profilometry and fluorescence microscopy,” Optics Letters 31, 2873 (2006).

  14. Chun-Chieh Wang, Junn-Yuan Lin, and Chau-Hwang Lee, “Membrane ripples of a living cell measured by non-interferometric wide-field optical profilometry,” Optics Express 13, 10665 (2005).

  15. Chau-Hwang Lee, Yu-Fen Chang, Chia-Hsuan Tsai, and Po-Hsiang Wang, “Optical measurement of the deformation of giant lipid vesicles driven by a micropipette electrode,” Langmuir 21, 7186 (2005).

  16. Shu-Wei Huang, Hong-Yao Mong, and Chau-Hwang Lee, “Super-resolution bright-field optical microscopy based on nanometer topographic contrast,” Microscopy Research and Technique 65, 180 (2004).

  17. Chau-Hwang Lee, Hui-Yu Chiang, and Hong-Yao Mong, “Sub-diffraction-limit imaging based on the topographic contrast of differential confocal microscopy,” Optics Letters 28, 1772 (2003).

  18. Chau-Hwang Lee, Hong-Yao Mong, and Wan-Chen Lin, “Noninterferometric wide-field optical profilometry with nanometer depth resolution,” Optics Letters 27, 1773 (2002).

  19. Chau-Hwang Lee, Wan-Chen Lin, and Jyhpyng Wang, “All-optical measurements of the bending rigidity of lipid-vesicle membranes across structural phase transitions,” Physical Review E 64, 020901(R) (2001).

  20. Chau-Hwang Lee, Wan-Chen Lin, and Jyhpyng Wang, “Using differential confocal microscopy to detect the phase transition of lipid vesicle membranes,” Optical Engineering 40, 2077 (2001).

  21. Chao-Wei Tsai, Chau-Hwang Lee, and Jyhpyng Wang, “Deconvolution of local surface response from topography in nanometer profilometry with a dual-scan method,” Optics Letters 24, 1732 (1999).

  22. Chau-Hwang Lee, Chinlin Guo, and Jyhpyng Wang, “Optical measurement of the viscoelastic and biochemical responses of living cells to mechanical perturbation,” Optics Letters 23, 307 (1998).

  23. Chau-Hwang Lee and Jyhpyng Wang, “Noninterferometric differential confocal microscopy with 2-nm depth resolution,” Optics Communications 135, 233 (1997).

 

  • International Conference Presentations:

  1. Y.-C. Chen and C.-H. Lee, “Three-dimensional particle tracking for quantitative assessment of molecular dynamics and cellular distribution,” Focus on Microscopy 2012 (Singapore).

  2. C.-H. Lee, T.-H. Liu, J.-L. Xiao, and J.-Y. Lin, “Using differential confocal microscopy to measure the membrane rigidity of a lipid vesicle in optical trap,” International Quantum Electronics Conference (IQEC)/Conference on Lasers and Electro-Optics (CLEO) Pacific Rim 2011 (Sydney, Australia), paper 149.

  3. Y.-C. Chen, H.-J. Pan, L.-W. Chu, C.-S. Yang, and C.-H. Lee, “An image processing algorithm to tackle noisy point spread functions in 3D intracellular particle tracking,” International Quantum Electronics Conference (IQEC)/Conference on Lasers and Electro-Optics (CLEO) Pacific Rim 2011 (Sydney, Australia), paper 494.

  4. Chau-Hwang Lee*, “Dynamical analyses of cell activities using high-resolution wide-field optical microscopy,” 2010 Taiwan–Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environmental Sciences (Hsin-Chu, Taiwan), September 9–10, 2010. (Keynote speech).

  5. C.-C. Wang, Y.-C. Kao, J.-Y. Lin, J.-Y. Cheng, and C.-H. Lee, “Asymmetric growth of cancer cell filopodia under electric field stimulation measured by structured illumination nano- profilometry,” Conference on Lasers and Electro-Optics 2010 (San Jose, California, USA), paper CThD5.

  6. C.-H. Lee, F.-C. Tsai, C.-C. Wang, and C.-P. Liang, “3D tracking of nano-carriers on living cells in bright-field images,” Focus on Microscopy 2010 (Shanghai, China).

  7. Chau-Hwang Lee, “Dynamical analyses of cell activities using high-resolution optical microscopy,” Japan–Taiwan Symposium on Nano-Medicine Research and Education (Kyoto, Japan), January 25, 2010. (invited talk)

  8. Chau-Hwang Lee, “Dynamical analyses of cell activities using bright-field optical profilometry and super-resolution imaging,” The 7th Cross-Strait Conference on Microscopy (Hua-Lian, Taiwan), August 28–30, 2009. (invited talk)

  9. J.-L. Xiao, P.-Y. Hsu, W.-Y. Liao, and C.-H. Lee, “Variations of membrane topography on living cells induced by laser light,” European Conferences on Biomedical Optics 2009 (Munich, Germany), paper WE5.

  10. T.-H. Hsu, M.-H. Yen, W.-Y. Liao, J.-Y. Cheng, and C.-H. Lee, “Label-free observation of asymmetric growth of cancer-cell filopodia in a culture chip,” European Conferences on Biomedical Optics 2009 (Munich, Germany), paper TuG7.

  11. C.-C. Wang and C.-H. Lee, “High-speed optical nano-profilometry with sub-diffraction-limit lateral resolution,” European Conferences on Biomedical Optics 2009 (Munich, Germany), paper TuG1.

  12. F.-C. Tsai, L.-A. Tai, Y.-J. Wang, J.-L. Xiao, C.-S. Yang, and C.-H. Lee, “Tracking three- dimensional motion of liposomes containing gold nanoparticles in living cells,” European Conferences on Biomedical Optics 2009 (Munich, Germany), paper SuE5.

  13. Chau-Hwang Lee, “Observation of cell membrane activities by using high-resolution optical microscopy,” 2009 The First Cross-Strait Bilateral Symposium on Biomedical Optics and Biophotonics (Fuzhou, China), paper C3. (invited talk)

  14. T.-H. Hsu, M.-H. Yen, W.-Y. Liao, J.-Y. Cheng, and C.-H. Lee, “Quantification of cancer-cell filopodium activities in a micro cell culture chamber using super-resolution bright-field optical microscopy,” International Conference on Laser Applications in Life Sciences (Taipei, Taiwan), December 4–6, 2008.

  15. F.-C. Tsai, L.-A. Tai, Y.-J. Wang, C.-S. Yang, and C.-H. Lee, “Tracking the 3D motion of liposomes containing Au nanoparticles in a living cell by using wide-field optical profilometry,” International Conference on Laser Applications in Life Sciences (Taipei, Taiwan), December 4–6, 2008.

  16. J.-Y. Lin, S.-H. Chou, R.-P. Huang, P.-S. Tsai, and C.-H. Lee, “Whole-field super-resolution optical sectioning microscopy using a single spatial light modulator,” International Conference on Laser Applications in Life Sciences (Taipei, Taiwan), December 4–6, 2008.

  17. Chau-Hwang Lee, “Membrane activities of a living cell characterized by three-dimensional optical tracking and widefield profilometry,” Optics and Photonics Japan 2008 (Tsukuba, Japan). (invited talk)

  18. C.-H. Lee, C.-C. Wang, C.-W. Lee, C.-Y. Huang, J.-Y. Lin, and P.-K. Wei, “Three- dimensional motion of a nanoparticle on the cell membrane observed by non-interferometric widefield optical profilometry,” in Conference on Lasers and Electro-Optics 2008 (San Jose, California, USA), paper CWM4.

  19. Chau-Hwang Lee, Chun-Chieh Wang, and Hung-Jhang Jian, “Particle movements and membrane deformations on a living cell measured by non-interferometric widefield optical profilometry,” in Focus on Microscopy 2008 (Osaka-Awaji, Japan).

  20. Chau-Hwang Lee, “Non-interferometric widefield optical profilometry (NIWOP): a new tool for observing cellular membrane dynamics,” in 3rd Asian and Pacific Rim Symposium on Biophotonics (Cairns, Australia, 2007) (invited talk).

  21. Chun-Chieh Wang, Hong-Jhang Jian, and Chau-Hwang Lee, “Transparent thin-film characterization by using differential optical sectioning interference microscopy,” in Conference on Lasers and Electro-Optics 2007 (Baltimore, Maryland, USA), paper CThCC5.

  22. C.-H. Lee, T.-H. Hsu, W.-Y. Liao, P.-C. Yang, C.-C. Wang, J.-L. Xiao, “Cancer cell filopodia characterized by super-resolution bright-field optical microscopy,” in Conference on Lasers and Electro-Optics 2007 (Baltimore, Maryland, USA), paper CTuEE6.

  23. Chau-Hwang Lee, “Membrane dynamics and mechanics characterized by high- resolution optical microscopy,” The 9th International Conference on Optics within Life Sciences (Taipei, Taiwan, 2006), paper O4-14 (invited talk).

  24. T.-H. Hsu, W.-Y. Liao, C.-C. Wang, J.-L. Xiao, P.-C. Yang, and C.-H. Lee, “Dynamics of cancer cell filopodia characterized by super-resolution bright-field optical microscopy,” The 9th International Conference on Optics within Life Sciences (Taipei, Taiwan, 2006), paper P2-2.

  25. Chun-Chieh Wang, Hsiao-Chao Chen, Jiunn-Yuan Lin, and Chau-Hwang Lee, “Applications of non-interferometric widefield optical profilometry on the studies of cellular membrane activities,” The 9th International Conference on Optics within Life Sciences (Taipei, Taiwan, 2006), paper P4-2

  26. Yu-Fen Chang, Yun-Ru Chen, and Chau-Hwang Lee, “Membrane fluctuations of a multiple-domain lipid vesicle measured by differential confocal microscopy,” Focus on Microscopy 2006 (Perth, Western Australia), p. 66.

  27. Chun-Chieh Wang, Jiunn-Yuan Lin, Hsiao-Chao Chen, and Chau-Hwang Lee, “Correlation between membrane ripples and underlying cytoskeletons of a living cell measured by non-interferometric widefield optical profilometry,” in Focus on Microscopy 2006 (Perth, Western Australia), p. 64.

  28. Kai-Wen Kuo, Jian-Long Xiao, and Chau-Hwang Lee, “Nanometer axial position sensing in optical tweezers by using differential confocal microscopy,” in Conference on Lasers and Electro-Optics 2005 (Baltimore, Maryland, USA), paper CFN7.

  29. Chau-Hwang Lee and Po-Hsiang Wang, “Using differential confocal microscopy to study voltage-induced membrane movements of lipid vesicles,” in Conference on Lasers and Electro-Optics 2004 (San Francisco, California, USA), paper CThT80.

  30. Po-Hsiang Wang, Hui-Yu Chiang, and Chau-Hwang Lee, “Converse-flexoelectric movement of lipid-vesicle membranes characterized by differential confocal microscopy,” in Conference on Lasers and Electro-Optics/Pacific Rim 2003 (Taipei, Taiwan), paper W4E-(12)-3.

  31. Chau-Hwang Lee, Hui-Yu Chiang, and Hong-Yao Mong, “Sub-diffraction-limit imaging based on the topographic contrast of differential confocal microscopy,” in Quantum Electronics and Laser Science Conference 2003 (Baltimore, Maryland, USA), paper QWA9.

  32. Chau-Hwang Lee and Wan-Chen Lin, “Non-interferometric wide-field optical profilometry with nanometer depth resolution,” in Conference on Lasers and Electro-Optics 2002 (Long Beach, California, USA), paper CMG4.

  33. Chau-Hwang Lee, Huei-Yu Chiang, and Hong-Yao Mong, “Super-resolution differential confocal microscopy,” in Focus on Microscopy 2002 (Kaoshiung, Taiwan, ROC), paper TaA6.

  34. Chau-Hwang Lee, Hong-Yao Mong, and Wan-Chen Lin, “Non-interferometric wide-field optical microscopy with nanometer depth resolution,” in Focus on Microscopy 2002 (Kaoshiung, Taiwan, ROC), paper MaB2.

  35. Chau-Hwang Lee, Wan-Chen Lin, and Jyhpyng Wang, “Mechanical aspects of lipid-bilayer phase transition studied by differential confocal microscopy,” in Conference on Lasers and Electro-Optics 2001 (Baltimore, Maryland, USA), paper CTuR4.

  36. Chau-Hwang Lee, Wan-Chen Lin, and Jyhpyng Wang, “Measuring the bending rigidity of giant unilamellar liposomes with differential confocal microscopy,” in Conference on Lasers and Electro-Optics 2000 (San Francisco, California, USA), paper CFF7.

  37. Chau-Hwang Lee, Wan-Chen Lin, and Jyhpyng Wang, “Using differential confocal microscopy to detect the phase transition of the membranes of giant unilamellar liposomes,” in Photonics Taiwan 2000 (Taipei, Taiwan), paper 4082-24.

  38. Chinlin Guo, Chau-Hwang Lee, and Jyhpyng Wang, “Signal transduction without activating surface receptors,” in 43rd Biophysical Society Annual Meeting (Baltimore, Maryland, USA, 1999). (Published in Biophysical Journal vol. 76, pt 2, p. A227.)

  39. Chao-Wei Tsai, Chau-Hwang Lee, and Jyhpyng Wang, “Deconvolution of local surface response from surface topography in optical profilometry by a dual-scan method,” in Conference on Lasers and Electro-Optics 1999 (Baltimore, Maryland, USA), paper CMD3.

  40. Chau-Hwang Lee, Chinlin Guo, and Jyhpyng Wang, “Nanometer imaging by differential confocal microscopy and its applications in biology,” in 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Hong Kong, 1998), paper 113.

  41. Chau-Hwang Lee, Chin-Lin Guo, and Jyhpyng Wang, “Application of differential confocal microscopy in the study of elastic response of living cells,” in Conference on Lasers and Electro-Optics 1997 (Baltimore, Maryland, USA), paper CTuD4.

  42. Chau-Hwang Lee and Jyhpyng Wang, “Differential confocal microscopy with nanometer depth resolution,” in Conference on Lasers and Electro-Optics 1996 (Anaheim, California, USA), paper CThK51.

  43. Jyhpyng Wang, Chau-Hwang Lee, Chun-Hung Lu, and Kung-Li Deng, “Differential confocal microscopy for imaging surface microstructures,” in Focus on Microscopy 1995 (Taipei, Taiwan, ROC). (Published in Zoological Studies, vol. 34, suppl. I, p. 44.)

 
  • Patents:

  1. Optical Profilometry. ROC (Taiwan) and US Patent pending.

  2. Optical Sectioning Microscopy. US Patent 8,019,136. ROC (Taiwan) and Japan Patent pending.

  3. Modulation Differential Confocal Microscopy. ROC (Taiwan) Patent I329207. US Patent pending.

  4. Method of Characterizing Transparent Thin-films Using Differential Optical Sectioning Interference Microscopy. ROC (Taiwan) Patent I328676. US Patent 7,545,510.

  5. Differential Confocal Microscopy. ROC (Taiwan) Patent 082212. US Patent 5,804,813

 

Ultrafast Laser Technology and EUV Light Sources

  • Journal Papers:

  1. M.-C. Chou, P.-H. Lin, H.-E. Tsai, D.-L. Chen, C.-H. Lee, J.-Y. Lin, J. Wang, and S.-Y. Chen, “Characterization and control of plasma density distribution for development of solid-target x-ray lasers,” Physical Review E 72, 026401 (2005).

  2. C.-H. Pai, S.-Y. Huang, C.-C. Kuo, M.-W. Lin, J. Wang, S.-Y. Chen, C.-H. Lee, and J.-Y. Lin, “Fabrication of spatial transient-density structures as high-field plasma photonic devices,” Physics of Plasmas 12, 070707 (2005).

  3. H.-H. Chu, H.-E. Tsai, M.-C. Chou, L.-S. Yang, J.-Y. Lin, C.-H. Lee, J. Wang, and S.-Y. Chen, “Collisional-excitation soft x-ray laser pumped by optical-field ionization in a cluster jet,” Physical Review A 71, 061804(R) (2005).

  4. T.-Y. Chien, C.-L. Chang, C.-H. Lee, J.-Y. Lin, J. Wang, and S.-Y. Chen, “Spatially localized self-injection of electrons in a self-modulated laser wakefield accelerator by using a laser-induced transient density ramp,” Physical Review Letters 94, 115003 (2005).

  5. H.-H. Chu, S.-Y. Huang, L.-S. Yang, T.-Y. Chien, Y.-F. Xiao, J.-Y. Lin, C.-H. Lee, S.-Y. Chen, and J. Wang, “A versatile 10-TW laser system with robust passive controls to achieve high stability and spatiotemporal quality,” Applied Physics B 79, 193 (2004).

  6. Y.-F. Xiao, H.-H. Chu, H.-E. Tsai, C.-H. Lee, J.-Y. Lin, J. Wang, and S.-Y. Chen, “Efficient generation of extended plasma waveguides with the axicon ignitor-heater scheme,” Physics of Plasmas 11, L21 (2004).

  7. H.-H. Chu, H.-E. Tsai, Y.-F. Xiao, C.-H. Lee, J.-Y. Lin, J. Wang, and S.-Y. Chen, “Control of laser beam propagation and absorption in a nanoplasma gas by programming of transient complex refractive index with a prepulse,” Physical Review E 69, 035403(R) (2004).

  8. W.-T. Chen, T.-Y. Chien, C.-H. Lee, J.-Y. Lin, J. Wang, and S.-Y. Chen, “Optically controlled seeding of Raman forward scattering and injection of electrons in a self-modulated laser wakefield accelerator,” Physical Review Letters 92, 075003 (2004).

  9. T.-Y. Chien, W.-T. Chen, Y.-H. Chen, C.-H. Lee, J.-Y. Lin, J. Wang, and S.-Y. Chen, “Prepulse controlled splitting of relativistically self-guided channel and suppression of Raman forward scattering instability,” Physics of Plasmas 11, 1173 (2004).

  10. J.-Y. Lin, H.-H. Chu, M.-Y. Shen, Y.-F. Xiao, C.-H. Lee, S.-Y. Chen, and J. Wang, “High-brightness soft x-ray generation under optimized laser-cluster interaction,” Optics Communications 231, 375 (2004).

  11. T.-W. Yau, C.-J. Hsu, H.-H. Chu, Y.-H. Chen, C.-H. Lee, J. Wang, and S.-Y. Chen, “Dependence of relativistic self-guiding and Raman forward scattering on duration and chirp of an intense laser pulse propagating in a plasma,” Physics of Plasmas 9, 391 (2002).

  12. Tai-Wei Yau, Chau-Hwang Lee, and Jyhpyng Wang, “Femtosecond self-focusing dynamics measured by three-dimensional phase-retrieval cross correlation,” Journal of the Optical Society of America B 17, 1626 (2000).

  13. Tai-Wei Yau, Chau-Hwang Lee, and Jyhpyng Wang, “Spatial-temporal field distribution of self-focused femtosecond pulses,” Ultrafast Phenomena XI, edited by T. Elsaesser, et al. (Springer-Verlag, Berlin, 1998), pp. 106–108.

  14. Yi-Yuh Hwang, Chau-Hwang Lee, and Jyhpyng Wang, “Dynamic model of multipass ultrashort-pulse laser amplifiers and its application,” Applied Optics 36, 7802 (1997).

  15. Chau-Hwang Lee, Jyhpyng Wang, and Yuh-Fwu Chou, “Femtosecond transform-limited Kerr-lens mode-locked dye lasers,” Optical and Quantum Electronics 28, 1443 (1996).

  16. Yuh-Fwu Chou, Chau-Hwang Lee, and Jyhpyng Wang, “Characteristics of a femtosecond transform-limited Kerr-lens mode-locked dye laser,” Optics Letters 19, 975 (1994).

 

  • International Conference Presentations:

  1. H.-H. Chu, H.-E. Tsai, L.-S. Yang, J.-Y. Lin, C.-H. Lee, J. Wang, and S.-Y. Chen, “Optical-field ionization x-ray laser with xenon cluster jet,” in SPIE Symposium on Optics & Photonics 2005 (San Diego, California, USA), paper 5919-30.

  2. H.-H. Chu, H.-E. Tsai, L.-S. Yang, J.-Y. Lin, C.-H. Lee, J. Wang, and S.-Y. Chen, “Optical-field-ionization EUV lasing in a xenon cluster jet,” in Quantum Electronics and Laser Science Conference 2005 (Baltimore, Maryland, USA), paper JThG5.

  3. H.-E. Tsai, H.-H. Chu, Y.-F. Xiao, C.-H. Lee, J.-Y. Lin, J. Wang, S.-Y. Chen, “Efficient generation of extended plasma waveguides with the axicon ignitor-heater scheme,” in International Quantum Electronics Conference 2004 (San Francisco, California, USA), paper ITuI40.

  4. H.-H. Chu, Y.-F. Xiao, H.-E. Tsai, C.-H. Lee, J.-Y. Lin, J. Wang and S.-Y. Chen, “Control of transient refractive index and laser beam propagation in a nanoplasma gas with a prepulse,” in International Quantum Electronics Conference 2004 (San Francisco, California, USA), paper JTuC2.

  5. T.-Y. Chien, W.-T. Chen, C.-H. Lee, J.-Y. Lin, J. Wang and S.-Y. Chen, “Control of seeding of Raman forward scattering and injection of electrons in a self-modulated laser wakefield accelerator by a co-propagating prepulse,” in International Quantum Electronics Conference 2004 (San Francisco, California, USA), paper JTuC1.

  6. H.-H. Chu, Y.-F. Xiao, M.-Y. Shen, J.-Y. Lin, C.-H. Lee, S.-Y. Chen, and J. Wang, “Optimization of soft x-ray emission from Ar clusters irradiated by high-intensity ultra-short laser pulses,” in Conference on Lasers and Electro-Optics 2003 (Baltimore, Maryland, USA), paper CMZ1.

  7. Y.-H. Chen, C.-J. Hsu, H.-H. Chu, T.-W. Yau, C.-H. Lee, J. Wang, and S.-Y. Chen, “Dependence of Raman forward scattering and relativistic self-guiding on duration and chirp of an intense laser pulse propagating in a plasma,” in Nonlinear Optics 2002 (Kauai, Hawaii, USA), paper TuC5.

  8. Tai-Wei Yau, Chau-Hwang Lee, and Jyhpyng Wang, “Uncollapsed self-focusing of femtosecond pulses in dielectric media due to the saturation of nonlinear refractive index,” in Quantum Electronics and Laser Science Conference 2000 (San Francisco, California, USA), paper QWI16.

  9. Tai-Wei Yau, Yuan-Yu Jau, Chau-Hwang Lee, and Jyhpyng Wang, “Photodiode-based phase-retrieval ultrafast waveform measurements,” in Conference on Lasers and Electro-Optics 1999 (Baltimore, Maryland, USA), paper CWF21.

  10. Tai-Wei Yau, Chau-Hwang Lee, and Jyhpyng Wang, “Spatial-temporal field distribution of self-focused femtosecond pulses,” in XIth International Conference on Ultrafast Phenomena (Garmisch-Partenkirchen, Germany, 1998), paper TuC2.

  11. Yi-Yuh Hwang, Ying-Hao Kuo, Chau-Hwang Lee, and Jyhpyng Wang, “Beam-profile evolution of trapped femtosecond pulses in Kerr media,” in Conference on Lasers and Electro-Optics 1997 (Baltimore, Maryland, USA), paper CTuP22.

  12. Yuh-Fwu Chou, Chau-Hwang Lee, and Jyhpyng Wang, “Femtosecond transform-limited self-starting Kerr-lens mode-locked dye laser,” in Conference on Lasers and Electro-Optics 1994 (Anaheim, California, USA), paper CThI14.

 

Micro/Nano Fabrications

  • Journal Papers:

  1. H.-Y. Hsieh, T.-W. Huang, J.-L. Xiao, C.-S. Yang, C.-C. Chang, C.-C. Chu, L.-W. Lo, S.-H. Wang, P.-C. Wang, C.-C. Chieng, C.-H. Lee, and F.-G. Tseng, “Fabrication and modification of dual-faced nano-mushrooms for tri-functional cell theranostics: SERS/fluorescence signaling, protein targeting, and drug delivering,” Journal of Materials Chemistry 22, 20918 (2012).

  2. H.-Y. Hsieh, J.-L. Xiao, C.-H. Lee, T.-W. Huang, C.-S. Yang, P.-C. Wang, and F.-G. Tseng, “Au-coated polystyrene nanoparticles with HAR nanocorrugations via surface carboxylation shielded anisotropic etching for significant SERS signal enhancement,” Journal of Physical Chemistry C 115, 16258 (2011).

  3. Yu-Fen Chang, Qiong-Ru Chou, Jiunn-Yuan Lin, and Chau-Hwang Lee, “Fabrication of high-aspect-ratio silicon nanopillar arrays with the conventional reactive ion etching technique,” Applied Physics A 86, 193 (2007).

  4. Chau-Hwang Lee, Ting-Wei Chang, Kuang-Li Lee, Jiunn-Yuan Lin, and Jyhpyng Wang, “Fabricating high-aspect-ratio sub-diffraction-limit structures on silicon with two-photon photopolymerization and reactive ion etching,” Applied Physics A 79, 2027 (2004).

 

  • International Conference Presentations:

  1. Yu-Fen Chang, Qiong-Ru Chou, Jiunn-Yuan Lin, and Chau-Hwang Lee, “Optimized reactive ion etching process for the fabrication of high-aspect-ratio silicon nanopillar arrays” in Micro TAS 2006 (Tokyo, Japan), paper 1010.

  2. Ting-Wei Chang, Hong-Yao Mong, Jiunn-Yuan Lin, Jyhpyng Wang, and Chau-Hwang Lee, “Controlling the feature size made by two-photon photopolymerization in a threshold material,” in Conference on Lasers and Electro-Optics 2003 (Baltimore, Maryland, USA), paper CTuL5.

  3. Ying-Ja Chen, Yi-Chun Chen, Chau-Hwang Lee, and Jyhpyng Wang, “High-aspect-ratio sub-diffraction-limit objects fabricated with two-photon- absorption photopolymerization,” in Conference on Lasers and Electro-Optics 2002 (Long Beach, California, USA), paper CTuN1.

 

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