鄭郅言

Ji-Yen Cheng

Education

  • Ph.D. Chemistry Department, National Taiwan University, TAIWAN, 1998
  • M.S. Chemistry Department, National Taiwan University, TAIWAN, 1992
  • B.S. Chemistry Department, National Taiwan University, TAIWAN, 1990

Research Fields

  • Cell-based micro analysis:cell migration in weak DC EF, cell-cell interaction co-culture chip, cellular chemotaxis, electrotaxis and metastasis, affinity binding and separation.
  • Rapid prototyping of microfluidic biochip and their biomedical applications.
  • Microarray technologies: flexible in-situ array synthesis, rapid hybridization, mRNA labeling chip, and portable DNA amplification chip.
  • Laser micromachining – mechanism and applications.

Experience

  • Deputy Director, 2023 ~
  • Executive Officer of Thematic Center Bio & Medical Application, 2021-2022
  • Executive Officer of the TCMES (Thematic Center of Mechanics and Engineering Sciences) 2015, Jan ~ 2020
  • Research Fellow, 2013, Sep ~
  • Associate Research Fellow, RCAS, Academia Sinica, Taiwan, 2007, May -2013 Sep
  • Assistant Research Fellow, RCAS, Academia Sinica, Taiwan, 2001-2007
  • Postdoctoral Fellow, IBMS, Academia Sinica, Taiwan, 1998-2001

Patents:

3D POLYMERIC INSERT TO APPLY UNIFORM ELECTRIC FIELD IN CIRCULAR CULTUREWARE 傳統細胞培養皿用之高效能均勻電場刺激裝置

Patent Granted: Europe, United Kingdom, France, 3350310, 2019, May 22
Provisional, US, Application number: 62/220,841, Application date 2018, Sep, 15
"雷射無碎裂微加工 Crack-free Glass Micromachining Using Laser", Cheng, J.-Y., 鄭郅言, Yen, M.-H. and 顏孟華. (2007) 台灣 patent no. I271252.
"生化反應晶片及其製法 Temperature Cycling Reaction Chip for Biological Reaction" Cheng, J.-Y., 鄭郅言, Hsieh, H.-J., 謝茜如, Chuang, Y.-C. and 莊永全. (2007) 台灣 patent no. I290954.
“流體驅動裝置及其製法”, “Apparatus and fabrication of microfluidic driving device”, Patent Granted, Taiwan Patent No. 258456, Jul, 2006.
"多管道寡核苷酸合成方法及裝置 Multi-channel Oligonucleotide Synthesis - Method and Device", Peck, K., 白果能, Cheng, J.-Y. and 鄭郅言. (2005) 台灣 patent no. I232867.
“Apparatus and Methods for Chemical Synthesis”, Konan Peck, Ji-Yen Cheng, 2002, Patent Granted, US Pat. No.6,867,050.

Publications

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices
Hui-Fang Chang, Shih-En Chou, Ji-Yen Cheng*
    Year:2020
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
Laser-induced silver nanoparticles with HfO2 shell for melamine detection
Lin*, H. Chen, I. Lu, W. 「Cheng, J. Y. 」Wang, J.
 [ DOI here ]    Year:2023-12
Sensor Actuat a-Phys
Inference detection and classification of illicit drugs by a modest Raman spectrometer with a convolutional neural network analyzer
Lai Yi-Ting, Wei Pei-Kuen, Kuo Chih-Yu, Cheng Ji-Yen
 [ DOI here ]    Year:2023-1
Sensors and Actuators B: Chemical
Miniaturized bioluminescent whole-cell sensor systems
Belkin Shimshon, 「Cheng Ji-Yen*」
 [ DOI here ]    Year:2023-08
Current Opinion in Biotechnology
Neurite growth induced by red light-caused intracellular reactive oxygen species production through cytochrome c oxidase activation
Kao, Y. C. Lin, G. Y. 「Cheng, J. Y.」 Lee*, C. H.
    Year:2023-04
J Photoch Photobio B
Engineering an integrated electroactive dressing to accelerate wound healing and monitor noninvasively progress of healing
Nguyen Nhien, Lin Zong-Hong, Barman Snigdha Roy, Korupalli Chiranjeevi, Cheng Ji-Yen, Song Ni-Xuan, Chang Yen, Mi Fwu-Long, Song Hsiang-Lin, Sung Hsing-Wen, Lin Yu-Jung
 [ DOI here ]    Year:2022-8
Nano Energy
Rapid printing of a Bacterial array for a Solid-Phase Assay (BacSPA) of heavy metal ions
Chien Tzu-Yun, Marín-Benavides Richard, Belkin Shimshon, Cheng Ji-Yen
 [ DOI here ]    Year:2022-5
Sensors and Actuators B: Chemical
Dispersion-enhancing surface treatment of AuNPs for a reduced probe loading and detection limit using t-SPR detection
Yeung Wing Kiu, Lo Shu-Cheng, Wang Sheng-Hann, Wei Pei-Kuen, Cheng Ji-Yen
 [ DOI here ]    Year:2021
The Analyst
Machine-learning assisted antibiotic detection and categorization using a bacterial sensor array
Huang Wei-Che, Wei Chin-Dian, Belkin Shimshon, Hsieh Tung-Han, Cheng Ji-Yen
 [ DOI here ]    Year:2021
Sensors and Actuators B: Chemical
Screening anti-metastasis drugs by cell adhesion-induced color change in a biochip
Chou Shih-En, Lee Kuang-Li, Wei Pei-Kuen, Cheng Ji-Yen
 [ DOI here ]    Year:2021
Lab on a Chip
Surface micromachining on a polymethylmethacrylate substrate using visible laser-induced backside wet etching with a KMnO4 solution as an absorber
Chang Hui-Fang, Yeung Wing Kiu, Kao Wei-Chen, Ehrhardt Martin, Zimmer Klaus, Cheng Ji-Yen
 [ DOI here ]    Year:2020-03
Journal of Laser Applications
High-Throughput and Dynamic Study of Drug and Cell Interactions Using Contrast Images in Aluminum-Based Nanoslit Arrays
Lee Kuang-Li, Hou Hsien-San, Cheng Ji-Yen, Wei Pei-Kuen
 [ DOI here ]    Year:2020
Analytical Chemistry
Promising urinary miRNA biomarkers t-SPR profiling for urothelial cell carcinoma
Yeung Wing Kiu, Li Hsiao-Fen, Chung Cheng-Lin, Lee Kuang-Li, Wei Pei-Kuen, Lin Heng, Chen Hsi-Hsien, Cheng Ji-Yen
 [ DOI here ]    Year:2020
Sensors and Actuators B: Chemical
A Smartphone-Based Whole-Cell Array Sensor for Detection of Antibiotics in Milk
Lu Mei-Yi, Kao Wei-Chen, Belkin Shimshon, Cheng Ji-Yen
 [ DOI here ]    Year:2019
Sensors
Doxycycline inhibits electric field-induced migration of non-small cell lung cancer (NSCLC) cells
Chang Hui-Fang, Cheng Hung-Tien, Chen Huai-Yi, Yeung Wing Kiu, Cheng Ji-Yen
 [ DOI here ]    Year:2019
Scientific Reports
Simultaneous assessment of cell morphology and adhesion using aluminum nanoslit-based plasmonic biosensing chips
Hou Hsien-San, Lee Kuang-Li, Wang Chen-Hung, Hsieh Tung-Han, Sun Juan-Jie, Wei Pei-Kuen, Cheng Ji-Yen
 [ DOI here ]    Year:2019
Scientific Reports
Multiplex detection of urinary miRNA biomarkers by transmission surface plasmon resonance
Yeung Wing Kiu, Chen Huai-Yi, Sun Juan-Jie, Hsieh Tung-Han, Mousavi Mansoureh Z., Chen Hsi-Hsien, Lee Kuang-Li, Lin Heng, Wei Pei-Kuen, Cheng Ji-Yen
 [ DOI here ]    Year:2018
The Analyst
Towards fast nanopattern fabrication by local laser annealing of block copolymer (BCP) films
Zimmer Klaus, Zajadacz Joachim, Frost Frank, Mayer Andre, Steinberg Christian, Chang Hui-Fang, Cheng Ji-Yen, Scheer Hella-Christin
 [ DOI here ]    Year:2018
Applied Surface Science
Towards fast nanopattern fabrication by local laser annealing of block T copolymer (BCP) films
Klaus Zimmer*, Joachim Zajadacz, Frank Frost, Andre Mayer, Christian Steinberg, Hui-Fang Chang, (Ji-Yen Cheng), Hella-Christin Scheer
    Year:2018
Applied Surface Science
Microbial biosensing of ciprofloxacin residues in food by a portable lens-free CCD-based analyzer
Kao Wei-Chen, Belkin Shimshon, (Cheng Ji-Yen)*
 [ DOI here ]    Year:2017
Analytical and Bioanalytical Chemistry
Use microfluidic chips to study the effects of ultraviolet lights on human fibroblasts
Huang Chien-Hsun, Hou Hsien-San, Lo Kai-Yin, 「Cheng Ji-Yen」, Sun Yung-Shin*
 [ DOI here ]    Year:2017
Microfluidics and Nanofluidics
Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli
Chou TY1 Sun YS, Hou HS, Wu SY, Zhu Y, Cheng JY, Lo KY*
 [ DOI here ]    Year:2016
JoVE (Journal of Visualized Experiment)
High-Quality Surface Micromachining on Polymer Using Visible-LIBWE
Ji-Yen Cheng*,, Wei-Chen Kao, Mansoureh Z. Mousavi, Hui-Fang Chang, Wen-Chi Hsu, Meng-Hua Yen, Martin Ehrhardt and Klaus Zimmer
 [ DOI here ]    Year:2016
Journal of Laser Micro Nanoengineering
Pulsed DC Electric Field–Induced Differentiation of Cortical Neural Precursor Cells
Chang Hui-Fang, Lee Ying-Shan, Tang Tang K., 「Cheng Ji-Yen*」
 [ DOI here ]    Year:2016
PLOS ONE
Uniform electric field generation in circular multi-well culture plates using polymeric inserts
Hsieh-Fu Tsai, Ji-Yen Cheng, Hui-Fang Chang, Tadashi Yamamoto, and Amy Q Shen*
    Year:2016
Scientific Reports
Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip
Hou,H.-S., Chang,H.-F. and (Cheng,J.-Y.)*
 [ DOI here ]    Year:2015-12
Journal of visualized Experiment
Programmable laser-assisted surface microfabrication on a polyvinyl alcohol-coated glass chip with self-changing cell adhesivity for heterotypic cell patterning
Li,Y.-C., Lin,M.-W., Yen,M.-H., Fan,M.-Y., Wu,J.-T., Young,T.-H., (Cheng,J.-Y.) and Lin,S.-J*
 [ DOI here ]    Year:2015-10
ACS Appl Mater Interfaces
A compact 3D-printed interface for coupling open digital microchips with Venturi easy ambient sonic-spray ionization mass spectrometry
Jie-Bi Hu, Ting-Ru Chen, Chia-Hsien Chang, [Ji-Yen Cheng], Yu-Chie Chen, and Pawel L Urban*
    Year:2015
ANALYST
Electrokinetic acceleration of DNA hybridization in microsystems
Kin Fong Lei*, Yun-Hsiang Wang, Huai-Yi Chen, Jia-Hong Sun, and [Ji-Yen Cheng]
 [ DOI here ]    Year:2015
TALANTA
Label-Free Detection of Rare Cell in Human Blood Using Gold Nano Slit Surface Plasmon Resonance
Mansoureh Mousavi, Huai-Yi Chen, Hsien-San Hou, Chou-Yuan-Yuan Chang, Steve Roffler, Pei-Kuen Wei, and [Ji-Yen Cheng*]
 [ DOI here ]    Year:2015
BIOSENSORS
Urinary Micro-RNA Biomarker Detection Using Capped Gold Nanoslit SPR in a Microfluidic Chip
Mansoureh Z Mousavi, Huai-Yi Chen, Kuang-Li Lee, Heng Lin, Hsi-Hsien Chen, Yuh-Feng Lin, Chung Shun Wong, Hsiao-Fen Li, Pei-Kuen Wei, and [Ji-Yen Cheng*]
 [ DOI here ]    Year:2015
ANALYST
Water pollutant monitoring by whole cell array through lens-free detection on CCD
Hsieh-Fu Tsai, Yi-Ching Tsai, Sharon Yagur-Kroll, Noa Palevsky, Shimshon Belkin and (Ji-Yen Cheng*)
 [ DOI here ]    Year:2015
LAB ON A CHIP
Modulating chemotaxis of lung cancer cells by using electric fields in a microfluidic device
Yu-Chiu Kao, Meng-Hua Hsieh, Chung-Chun Liu, Huei-Jyuan Pan, Wei-Yu Liao, (Ji-Yen Cheng), Po-Ling Kuo, and Chau-Hwang Lee*
 [ DOI here ]    Year:2014
Biomicrofluidics
Simultaneous chemical and electrical stimulation on lung cancer cells using a multichannel-dual-electric-field chip
Hsien-San Hou, Hsieh-Fu Tsai, Hsien-Tai Chiu, and (Ji-Yen Cheng*)
 [ DOI here ]    Year:2014
Biomicrofluidics
Crack-free Microfabrication of Glass Ceramic Using Visible LIBWE
(Ji-Yen Cheng*), Huai-Yi Chen, Mansoureh Seyedehmansoureh Zarei Mousavi, Chia-Hao Chang, and Chou-Yuan-Yuan Chang
    Year:2013-12
Journal of Laser Micro Nanoengineering
Evaluation of EGFR and RTK Signaling in the Electrotaxis of Lung Adenocarcinoma Cells under Direct-Current Electric Field Stimulation
Hsieh-Fu Tsai, Ching-Wen Huang, Hui-Fang Chang, Jeremy J W Chen, Chau-Hwang Lee, and (Ji-Yen Cheng)*
    Year:2013-09
PLoS One
Magnetic nanoparticle-enhanced SPR on gold nanoslits for ultra-sensitive, label-free detection of nucleic acid biomarkers
Mansoureh Z Mousavi, Huai-Yi Chen, Shu-Han Wu, Shih-Wei Peng, Kuang-Li Lee, Pei-Kuen Wei, and (Ji-Yen Cheng*)
    Year:2013-02
ANALYST
Electrotaxis of oral squamous cell carcinoma cells in a multiple-electric-field chip with uniform flow field
Tsai, H.-F.; Peng, S.-W.; Wu, C.-Y.; Chang, H.-F.; (Cheng, J.-Y)*
    Year:2012-10
Biomicrofluidics
In vitro electrical-stimulated wound-healing chip for studying electric field-assisted wound-healing process
Sun, Y.-S.; Peng, S.-W.; (Cheng, J.-Y)*
    Year:2012-10
Biomicrofluidics
Electrotaxis of lung cancer cells in ordered three-dimensional scaffolds
Sun, Y.-S.; Peng, S.-W.; Lin, K.-H.; (Cheng, J.-Y)*
    Year:2012-06
Biomicrofluidics
Enhanced localized plasmonic detections using partially-embedded gold nanoparticles and ellipsometric measurements
Moirangthem, R. S.; Yaseen, M. T.; Wei, P.-K.; (Cheng, J.-Y.); Chang, Y.-C*
    Year:2012-04
BIOMEDICAL OPTICS EXPRESS
Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip
Chun-Chieh Wang,Yu-Chiu Ka,Pei-Yin Chi,Ching-Wen Huang,Jiunn-Yuan Lin,Chia-Fu Chou,(Ji-Yen Cheng)*,Chau-Hwang Lee
    Year:2011
LAB ON A CHIP
Blue light emission from a glass/liquid interface for real-time monitoring of a laser-induced etching process
Ji-Yen Cheng*, Mansoureh Z Mousavi, Chun-YingWu, and Hsieh-Fu Tsai
 [ DOI here ]    Year:2011
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Dielectrophoresis-based cellular microarray chip for anticancer drug screening in perfusion microenvironments
Lo-Chang Hsiung, Chi-Ling Chiang, Chen-Ho Wang, Yu-Hsu Huang, Ching-Te Kuo, Ji-Yen Cheng, Ching-Hung Lin, Victoria Wu, Hsien-Yeh Chou, De-Shien Jong, Hsinyu Lee and Andrew M. Wo
    Year:2011
LAB ON A CHIP
Gene Expression of Human Lung Cancer Cell Line CL1–5 in Response to a Direct Current Electric Field
Ching-Wen Huang, Huai-Yi Chen, Meng-Hua Yen, Jeremy J. W. Chen, Tai-Horng Young, Ji-Yen Cheng*
    Year:2011
PLoS One
Crack-free micromachining on glass substrates by visible LIBWE using liquid metallic absorbers
Yen, Meng-Hua,Huang, Ching-Wen,Hsu, Wen-Chi,Young, Tai-Horng,Zimmer, Klaus,(Cheng, Ji-Yen)*
    Year:2010
APPLIED SURFACE SCIENCE
Electrotaxis of lung cancer cells in a multiple-electric-field chip
Ching-Wen Huang, Ji-Yen Cheng∗, Meng-Hua Yen, Tai-Horng Young
    Year:2009-05
BIOSENSORS & BIOELECTRONICS
Microfluidic ARray Synthesizer (MArS) for Rapid Preparation and Hybridization of Custom DNA Microarray
Ji-Yen Cheng*, Huai-Yi Chen
    Year:2009-04
BIOTECHNOLOGY AND BIOENGINEERING
Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip
Hsu, T.-H., Yen, M.-H., Liao, W.-Y., Cheng*, J.-Y. and Lee*, C.-H.
    Year:2009-01
LAB ON A CHIP
A planar interdigitated ring electrode array via dielectrophoresis for uniform patterning of cells.
14.\tHsiung, L.-C., Yang, C.-H., Chiu, C.-L., Chen, C.-L., YuehWang, Lee, H., Cheng, J.-Y., Ho, M.-C. and M.Wo*
    Year:2008
BIOSENSORS & BIOELECTRONICS
A transparent cell culture microchamber with variablly controlled concentration gradient generator and flow field rectifier
15.\tCheng,* J.-Y., Yen, M.-H., Kuo, C.-T. and Young, T.-H.
    Year:2008
Biomicrofluidic
ITO patterning by a low power Q-switched green laser and its use in the fabrication of a transparent flow meter
12.\tCheng*, J.-Y., Yen, M.-H., Hsu, W.-C., Jhang, J.-H. and Young, T.-H.
    Year:2007
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Crack-free micromachining on glass using an economic green laser
Cheng*, J.-Y., Yen, M.-H. and Young, T.-H.
    Year:2006
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Elucidating in vitro Cell-Cell Interaction Using a Microfluidic Coculture System
Wei, C.-W., Cheng*, J.-Y. and Young, T.-H.
    Year:2006
BIOMEDICAL MICRODEVICES
Rapid cell-patterning and microfluidic chip fabrication by crack-free CO2 laser ablation on glass
Wei, C.-W., Cheng*, J.-Y. and Young, T.-H.
    Year:2006
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Crack-free direct-writing on glass using a low-power UV laser in the manufacture of a microfluidic chip
Cheng, J.-Y.*, Yen, M.-H., Wei, C.-W., Chuang, Y.-C. and Young, T.-H.
    Year:2005-10
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Performing microchannel temperature cycling reactions using reciprocating reagent shuttling along radial temperature gradient
Cheng, J.-Y.*, Hsieh, C.-J. and Chuang, Y.-C.
    Year:2005-09
ANALYST
Simple method in diagnosing cancer cells by a novel fluorescence probe BMVC
Kang, C.-C., Chang, C.-C., Cheng, J.-Y. and Chang*, T.-C.
    Year:2005
Journal of Chinese Chemistry Society
Using a microfluidic device for 1 microliter DNA microarray hybridization in 500 seconds
Wei, C.-W., Cheng, J.-Y.*, Huang, C.-T., Yen, M.-H. and Young, T.-H.
    Year:2005
NUCLEIC ACIDS RESEARCH
Cost-effective trapezoidal modified Boyden chamber with comparable accuracy to a commercial,
Chou, R.-H., Lin, K.-C., Lin, S.-C., Cheng, J.-Y., Wu, C.-W. and Chang, W.-S.W.*
    Year:2004
BIOTECHNIQUES
Direct-write Laser Micromachining and Universal Surface Modification of PMMA for Device Development,
Cheng, J.-Y.*, Wei, C.-W., Hsu, K.-H. and Young, T.-H.
    Year:2004
SENSORS AND ACTUATORS B-CHEMICAL
Electrowetting (EW)-Based Valve Combined with Hydrophilic Teflon Microfluidic Guidance in Controlling Continuous Fluid Flow
Cheng, J.-Y.* and Hsiung, L.-C
    Year:2004
BIOMEDICAL MICRODEVICES