1993-1997 Ph.D. in Electrical Engineering, National Taiwan University.
1992-1993 M.S. student in Graduate Institute of Electro-Optical Engineering, National Taiwan University.
1988-1992 B.S. in Electrical Engineering, National Taiwan University.
1985-1988 Taipei Municipal Chien Kuo Senior High School.
Experience：
Deputy Executive Secretary (2016-present), Central Academic Advisory Committee, Academia Sinica.
Joint-appointment Professor (2014-present), Professor and Chairman (2011-2014), Institute of Biophotonics, National Yang-Ming University.
2012 Academia Sinica Research Award for Junior Research Investigators.
2010 Dr. Ta-You Wu Memorial Award, National Science Council, Taiwan.
Research Fellow, Research Center for Applied Sciences, Academia Sinica (2010–present).
Joint-appointment Assistant and Associate Professor, Institute of Biophotonics, National Yang-Ming University (2003–2011).
Assistant to Associate Research Fellow, Research Center for Applied Sciences, Academia Sinica (2000–2010).
Postdoctoral Research Associate, Institute of Atomic and Molecular Sciences, Academia Sinica (1997–1999).
Excellent Ph.D. Thesis Award of the R.O.C. Optical Engineering Society (1997).
Research Fields：
Cell-cell and cell-microenvironment interactions.
Super resolution far-field optical microscopy.
Differential sectioning microscopy.
Mechanical and electrical characteristics of bio-membranes.
Laser-assisted micro/nano fabrication.
Recent Publications：
H.‐H. Hou, H.‐J. Pan, W.‐Y. Liao, C.-H. Lee, and C.‐J. Yu, "Autophagy in fibroblasts induced by cigarette smoke extract promotes invasion in lung cancer cells," International Journal of Cancer 147, 2587 (2020).
Y.-C. Kao, Y.-C. Liao, P.-L. Cheng, and C.-H. Lee, "Neurite regrowth stimulation by a red-light spot focused on the neuronal cell soma following blue light-induced retraction," Scientific Reports 9, 18210 (2019).
C.-W. Lee, Y.-L. Chiang, J.-T. Liu, Y.-X. Chen, C.-H. Lee, Y.-L. Chen, and I.-S. Hwang, "Emerging roles of air gases in lipid bilayers," Small 14, 1802133 (2018).
C.-H. Chang, H.-H. Lee, and C.-H. Lee, "Substrate properties modulate cell membrane roughness by way of actin filaments," Scientific Reports 7, 9068 (2017).
B.-M. Chen, M. A. Al-Aghbar, C.-H. Lee, T.-C. Chang, Y.-C. Su, Y.-C. Li, S.-E. Chang, C.-C. Chen, T.-H. Chung, Y.-J. Liao, C.-H. Lee, and S. Roffler, "The affinity of elongated membrane-tethered ligands determines potency of T cell receptor triggering,” Frontiers in Immunology 8, 793 (2017).
C.-W. Lee, C.-C. Wang, and C.-H. Lee, "Mechanoprofiling on membranes of living cells with atomic force microscopy and optical nano-profilometry," Advances in Physics： X 2, 608 (2017).
Y.-C. Kao, J.-R. Jheng, H.-J. Pan, W.-Y. Liao, C.-H. Lee, and P.-L. Kuo, "Elevated hydrostatic pressure enhances the motility and enlarges the size of the lung cancer cells through aquaporin upregulation mediated by caveolin-1 and ERK1/2 signaling," Oncogene 36, 863 (2017).
L. K. Chin, C.-H. Lee, and B.-C. Chen, "Imaging live cells at high spatiotemporal resolution for lab-on-a-chip applications," Lab on a Chip 16, 2014 (2016).
P. Y. Liu, L. K. Chin, W. Ser, H. F. Chen, C.-M. Hsieh, C.-H. Lee, K.-B. Sung, T. C. Ayi, P. H. Yap, B. Liedberg, K. Wang, T. Bourouinaj, and Y. Leprince-Wang, "Cell refractive index for cell biology and disease diagnosis： past, present and future," Lab on a Chip 16, 634 (2016)
C.-W. Lee, L.-L. Jang, H.-J. Pan, Y.-R. Chen, C.-C. Chen, and C.-H. Lee, "Membrane roughness as a sensitive parameter reflecting the status of neuronal cells in response to chemical and nanoparticle treatments," Journal of Nanobiotechnology 14, 9 (2016).
B. Patra, C.-C. Peng, W.-H. Liao, C.-H. Lee, and Y.-C. Tung, "Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device," Scientific Reports 6, 21061 (2016).
Y.-H. Su, P.-C. Chiang, L.-J. Cheng, C.-H. Lee, N. S. Swami, and C.-F. Chou, "High aspect ratio nanoimprinted grooves of poly(lactic-co-glycolic acid) control the length and direction of retraction fibers during fibroblast cell division," Biointerphases 10, 041008 (2015).
C.-C. Lan, E. Y. Lu, H.-J. Pan, and C.-H. Lee, "Directional migration of cancer cells induced by a blue light intensity gradient," Biomedical Optics Express 6, 2624 (2015).
Y.-F. Hsiao, H.-J. Pan, Y.-C. Tung, C.-C. Chen, and C.-H. Lee, "Effects of hydraulic pressure on cardiomyoblasts in a microfluidic device," Biomicrofluidics 9, 024111 (2015).
W.-Y. Liao, C.-C. Ho, H.-H. Hou, T.-H. Hsu, M.-F. Tsai, K.-Y. Chen, H.-Y. Chen, Y.-C. Lee, C.-J. Yu, C.-H. Lee, and P.-C. Yang, "Heparin cofactor II enhances cell motility and promotes metastasis in non-small-cell lung cancer," Journal of Pathology 235, 50 (2015).
B. Patra, Y.-S. Peng, C.-C. Peng, W.-H. Liao, Y.-A. Chen, K.-H. Lin, Y.-C. Tung, and C.-H. Lee, "Migration and vascular lumen formation of endothelial cells in cancer cell spheroids of various sizes," Biomicrofluidics 8, 052109 (2014).
Y.-C. Kao, M.-H. Hsieh, C.-C. Liu, H.-J. Pan, W.-Y. Liao, J.-Y. Cheng, P.-L. Kuo, and C.-H. Lee, "Modulating chemotaxis of lung cancer cells by using electric fields in a microfluidic device," Biomicrofluidics 8, 024107 (2014).
Y.-R. Liou, W. Torng, Y.-C. Kao, K.-B. Sung, C.-H. Lee, and P.-L. Kuo, "Substrate stiffness regulates filopodial activities in lung cancer cells,” PLoS ONE 9, e89767 (2014).
L.-W. Chu, Y.-L. Huang, J.-H. Lee, L.-Y. Huang, W.-J. Chen, Y.-H. Lin, J.-Y. Chen, R. Xiang, C.-H. Lee, and Y.-H. Ping, "Single-virus tracking approach to reveal the interaction of Dengue virus with autophagy during the early stage of infection," Journal of Biomedical Optics 19, 011018 (2014).
H.-J. Pan, R.-L. Wang, J.-L. Xiao, Y.-J. Chang, J.-Y. Cheng, Y.-R. Chen, and C.-H. Lee, "Using optical profilometry to characterize cell membrane roughness influenced by amyloid-beta 42 aggregates and electric fields," Journal of Biomedical Optics 19, 011009 (2014).
B. Patra, Y.-H. Chen, C.-C. Peng, S.-C. Lin, C.-H. Lee, and Y.-C. Tung, "A microfluidic device for uniform-sized cell spheroids formation, culture, harvesting and flow cytometry analysis," Biomicrofluidics 7, 054114 (2013).
H.-F. Tsai, C.-W. Huang, H.-F. Chang, J. J. W. Chen, C.-H. Lee, and J.-Y. Cheng, "Evaluation of EGFR and RTK signaling in the electrotaxis of lung adenocarcinoma cells under direct-current electric field stimulation," PLoS ONE 8, e73418 (2013).
J.-L. Xiao, D.-H. Lu, and C.-H. Lee, "Guiding the migration of adherent cells by using optical micropatterns," Applied Physics Letters 102, 123703 (2013).
J.-W. Huang, H.-J. Pan, W.-Y. Yao, Y.-W. Tsao, W.-Y. Liao, C.-W. Wu, Y.-C. Tung, and C.-H. Lee, "Interaction between lung cancer cell and myofibroblast influenced by cyclic tensile strain," Lab on a Chip 13, 1114 (2013).
Patents：
Height measurement by correlating intensity with position of scanning object along optical axis of a structured illumination microscope. US Patent 8,705,043, ROC (Taiwan) Patent I438392.
Optical Sectioning Microcopy, US Patent 8,019,136, Japan Patent 5085608, ROC (Taiwan) Patent I414818.
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