Yu-Jung Lin 林鈺容
Assistant Research Fellow

Ways to contact me：

E-mail:linyujunggate.sinica.edu.tw
Phone:02-2787-3144
Fax: 02-2787-3122
Website:
Address: Research Center for Applied Sciences, Academia Sinica
128 Academia Road, Section 2, Nankang, Taipei 115-29, Taiwan R.O.C
中央研究院應用科學研究中心
台北市11529南港區研究院路二段128號
跨領域科技大樓

Education：

Experience：

Research Fields：

  • Development of Drug Delivery System

  • Biomaterials

  • Nanomedicine

Recent Publications：

  1. Nguyen, N., Lin, Z. H., Barman, S. R. Korupalli, C., Cheng, J. Y., Song, N. X., Chang, Y., Mi, F. L., Song, H. L., Sung, H. W.*,Lin, Y. J.* Engineering an integrated electroactive dressing to accelerate wound healing and monitor noninvasively progress of healing. Nano Energy 2022, 99, 107393.

  2. Mac, C. H., Chan, H. Y., Lin, Y. H., Sharma, A. K., Song, H. L., Chan, Y. S., Lin, K. J.*, Lin. Y. J.*, Sung, H. W.* Engineering a biomimetic bone scaffold that can regulate redox homeostasis and promote osteogenesis to repair large bone defects. Biomaterials 2022, 286, 121574.

  3. Miao, Y. B.†, Lin, Y. J.†, Chen, K. H.†, Luo, P. K., Chuang S. H., Yu, Y. T., Tai, H. M., Chen, C. T., Lin, K. J., Sung, H. W. Engineering nano- and microparticles as oral delivery vehicles to promote intestinal lymphatic drug transport. Advanced Materials 2021, 33, e2104139. (†Equal Contribution)

  4. Miao, Y. B., Chen, K. H., Chen, C. T., Mi, F. L., Lin, Y. J., Chang, Y., Chiang, C. S., Wang, J. T., Lin, K. J., Sung, H. W. A noninvasive gut-to-brain oral drug delivery system for treating brain tumors. Advanced Materials 2021, 33, e2100701.

  5. Korupalli, C., Li, H., Nguyen, N., Mi, F. L., Chang, Y., Lin, Y. J.*, Sung, H. W*. Conductive materials for healing wounds: their incorporation in electroactive wound dressings, characterization, and perspectives. Advanced Healthcare Materials 2021, 10, e2001384.

  6. Lin, Y. J., Chen, C. C., Nguyen, D., Su, H. R., Lin, K. J., Chen, H. L., Hu, Y. J., Lai, P. L., Sung, H. W. Biomimetic engineering of a scavenger-free nitric oxide-generating/delivering system to enhance radiation therapy. Small 2020, 16, e2000655. (Selected as Inside Cover)

  7. Wan, W. L., Tian, B., Lin, Y. J., Korupalli, C., Lu, M. Y., Cui, Q., Wan, D., Chang, Y., Sung, H. W. Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS. Nature Communications 2020, 11, 534.

  8. Cui, Q., Le, T. H., Lin, Y. J., Miao, Y. B., Sung, I. T., Tsai, W. B., Chan, H. Y., Lin, Z. H., Sung, H. W. A self-powered battery-driven drug delivery device that can function as a micromotor and galvanically actuate localized payload release. Nano Energy 2019, 66, 104120.

  9. Lin, Y. J., Mi, F. L., Lin, P. Y., Miao, Y. B., Huang, T., Chen, K. H., Chen, C. T., Chang, Y., Sung, H. W. Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems. Advanced Drug Delivery Reviews 2019, 139, 71–82.

  10. Lin, Y. J., Chen, C. C., Chi, N. W., Nguyen, T., Lu, H. Y., Nguyen, D., Lai, P. L., Sung, H. W. In situ self-assembling micellar depots that can actively trap and passively release NO with long-lasting activity to reverse osteoporosis. Advanced Materials 2018, 30, e1705605.

  11. Wan, W. L.†, Lin, Y. J.†, Shih, P. C., Bow, Y. R., Cui, Q., Chang, Y., Chia, W. T., Sung, H. W. An in situ depot for continuous evolution of gaseous H2 mediated by a magnesium passivation/activation cycle for treating osteoarthritis. Angewandte Chemie International Edition 2018, 57, 9875–9879. (†Equal Contribution)

  12. Yeh, C. M., Lin, Y. J., Hsu, T. H., Ruan, T. Genistein suppressing the ROS-induced hypersensitivity of rat vagal lung C-fiber afferents through an ERα-mediated mechanism. Chinese Journal of Physiology 2018, 61, 14–24.

  13. Lin, Y. J., Huang, C. C., Wan, W. L., Chiang, C. H., Chang, Y., Sung, H. W. Recent advances in CO2 bubble-generating carrier systems for localized controlled release. Biomaterials 2017, 133, 154–164.

  14. Wan, W. L., Lin, Y. J., Chen, H. L., Huang, C. C., Shih, P. C., Bow, Y. R., Chia, W. T., Sung, H. W. In situ Nanoreactor for photosynthesizing H2 gas to mitigate oxidative stress in tissue inflammation. Journal of the American Chemical Society 2017, 139, 12923–12926.

  15. Lin, W. C., Huang, C. C., Lin, S. J., Li, M. J., Chang, Y., Lin, Y. J., Wan, W. L., Shih, P. C., Sung, H. W. In situ depot comprising phase-change materials that can sustainably release a gasotransmitter H2S to treat diabetic wounds. Biomaterials 2017, 145, 1–8.

  16. Yeh, C. M., Ruan, T., Lin, Y. J., Hsu, T. H. Activation of cannabinoid CB1 receptors suppresses the ROS-induced hypersensitivity of rat vagal lung C-fiber afferents. Pulmonary Pharmacology and Therapeutics 2016, 40, 22–29.

  17. Pan, W. Y., Lin, K. J., Huang, C. C., Chiang, W. L., Lin, Y. J., Lin, W. C., Chuang, E. Y., Chang, Y., Sung, H. W. Localized sequence-specific release of a chemopreventive agent and an anticancer drug in a time-controllable manner to enhance therapeutic efficacy. Biomaterials 2016, 101, 241–50.

  18. Lin, Y. J., Lin, R. L., Ruan, T., Khosravi, M., Lee, L. Y. A synergistic effect of simultaneous TRPA1 and TRPV1 activations on vagal pulmonary C-fiber afferents. Journal of Applied Physiology 2015, 118, 273–281.

  19. Lin, Y. J., Lin, R. L., Khosravi, M., Lee, L. Y. Hypersensitivity of vagal pulmonary C-fibers induced by increasing airway temperature in ovalbumin-sensitized rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2015, 309, R1285–1291.

  20. Lin, R. L., Lin, Y. J., Xu, F., Lee, L. Y. Hemorrhagic hypotension-induced hypersensitivity of vagal pulmonary C-fibers to chemical stimulation and lung inflation in anesthetized rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2015, 308, R605–613.

  21. Liu, B. Y., Lin, Y. J., Lee, H. F., Ho, C. Y., Ruan, T., Kou, Y. R. Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal reflux disease: the role of TRPM8. Journal of Applied Physiology 2015, 118, 635–645.

  22. Lee, L. Y., Hsu, C. C., Lin, Y. J., Lin, R. L., Khosravi, M. Interaction between TRPA1 and TRPV1: synergy on pulmonary sensory nerves. Pulmonary Pharmacology and Therapeutics 2015, 35, 87–93.

  23. Chung, M. F., Chia, W. T., Wan, W. L., Lin, Y. J., Sung, H. W. Controlled release of an anti-inflammatory drug using an ultrasensitive ROS-responsive gas-generating carrier for localized inflammation inhibition. Journal of the American Chemical Society 2015, 137, 12462–12465.

  24. Ruan, T., Lin, Y. J., Hsu, T. H., Lu, S. H., Jow, G. M., Kou, Y. R. Sensitization by pulmonary reactive oxygen species of rat vagal lung C-fibers: the roles of the TRPV1, TRPA1, and P2X receptors. PLoS One 2014, 9, e91763.

  25. Lin, Y. J., Lin, Y. S., Lai, C. J., Yuan, Z. F., Ruan, T., Kou, Y. R. Perivagal antagonist treatment in rats selectively blocks the reflex and afferent responses of vagal lung C fibers to intravenous agonists. Journal of Applied Physiology 2013, 114, 361–370.

  26. Lin, Y. J., Hsu, H. H., Ruan, T., Kou, Y. R. mediator mechanisms involved in TRPV1, TRPA1 and P2X receptor-mediated sensory transduction of pulmonary ROS by vagal lung C-fibers in rats. Respiratory Physiology & Neurobiology 2013, 189, 1–9.

  27. Lin, R. L., Lin, Y. J., Geer, M. J., Kryscio, R., Lee, L. Y. Pulmonary chemoreflex responses are potentiated by tumor necrosis factor-alpha in mice. Journal of Applied Physiology 2013, 114, 1536–1543.

Patents：

  1. "溫度反應型組成物、其製備方法及其用途" 宋信文, 林鈺容, 紀乃文, 萬瑋琳. 中華民國專利(證書號：I606829)