Narrative CV

陳培菱教授目前擔任應用科學中心研究員專精於生醫材料與生物影像技術開發。他的研究興趣聚焦於奈米醫學領域尤其致力探討奈米粒子與腫瘤之間的交互作用。他們的研究團隊致力開發多種奈米粒子與影像工具以深入了解奈米粒子到達及累積在腫瘤的機制。陳教授畢業於美國加州大學爾灣分校並獲得化學博士過去數年陳教授已應邀在國際會議發表超過七十場演講包括全體大會與主題演講並主辦超過二十場國際研討會。

陳培菱教授的研究團隊開發的即時雙光子活體影像技術在相關領域受到高度肯定。他們協助多位醫師透過動物疾病模型深入理解疾病機制並透過量化藥物載體在不同疾病模型中的分佈情形協助優化藥物遞送效率展現學術研究成果直接促進醫療實務應用的效益。

近年來陳培菱教授已主導超過四項跨領域合作研究計畫。身為計畫總主持人陳教授成功促進不同領域專家的深度交流與合作。此外為推廣奈米醫學研究發展陳教授共同創立台灣奈米醫學學會並擔任常務監事;同時擔任台灣奈米科技產業發展協會副理事長以及位於新加坡之亞洲奈米論壇執行委員積極推動奈米技術的產業化及國際合作。身為導師陳教授已指導十位研究生培育未來奈米科技人才。

Education

• Department of Chemistry, National Taiwan University, B.S., 1990
• Department of Chemistry, University of California, Irvine. Ph.D. 1998

Positions and Career

• 中央研究院應用科學研究中心智慧生物工程專題中心執行長 (2023-2024)
• 中央研究院應用科學研究中心 研究員 (2010-present)
• 中央研究院物理所合聘研究員 (2021-present)
• 台灣奈米技術產業發展協會 理事 (2022-present)
• 台灣奈米生醫學會 常務監事 (2019)
• 日本京都大學訪問教授 (2015)
• 日本理化研究所訪問教授 (2012)
• 中央研究院應用科學研究中心光電專題中心執行長 (2012)
• 中央研究院應用科學研究中心 副主任 (2010-2012)
• 中央研究院應用科學研究中心 副研究員 (2005-2010)
• 中央研究院應用科學工程所籌備處 助研究員 (2001-2005)
• 美國加州大學柏克萊分校 博士後研究員 (1999-2001)

Honors and Awards

• 2021 中研院 深耕計畫
• 2019 英國皇家化學學會會士
• 2009 中研院 前瞻計畫
• 2007 中研院 年輕學者
• 2007 國科會 吳大猷獎

Selected Publications

• Zih-An Chen, Cheng-Hsun Wu, Si-Han Wu, * Chiung-Yin Huang, Chung-Yuan Mou, Kuo-Chen Wei, Yun Yen, I-Ting Chien, Sabiha Runa, Yi-Ping Chen,* Peilin Chen* "Receptor Ligand-Free Mesoporous Silica Nanoparticles: Streamlined Strategy for Targeted Drug Delivery Across the Blood-Brain Barrier" ACS Nano, 2024, 18, 12716.
• Chi-Shan Li, et al., "Cytosolic galectin-4 enchains bacteria, restricts their motility and promotes inflammasome activation in intestinal epithelial cells "Proc. Natl. Acad. Sci. U.S.A., 2023, 12, e2207091120.
• Yuan-Yuan Cheng, et al., "Metabolic changes associated with cardiomyocyte dedifferentiation enable adult mammalian cardiac regeneration." Circulation, 2022, 146, 1950.
• Wei-Chun Tang, Yen-Ting Liu, Cheng-Han Yeh, Chieh-Han Lu, Chiao-Hui Tu, Yi-Ling Lin, Yu-Chun Lin, Tsui-Ling Hsu, Liang Gao, Shu-Wei Chang, Peilin Chen* and Bi-Chang Chen* "Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy" Communications Biology, 2022, 5, 879.
• Chiung Wen Kuo, Feby Wijaya Pratiwi, Yen-Ting Liu, Di-Yen Chueh and Peilin Chen* "Revealing the nanometric structural changes in myocardial infarction models by time-lapse intravital imaging" Frontiers in Bioengineering and Biotechnology, 2022, 10, 935415.
• San-Shan Huang, et al., "Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer" Science Advances, 2021, 7, eabf2400.
• Hung-Lin Chen, et.al., "Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis" (20201) J. Clin. Invest. 131, e130704.
• Rong-Lin Chang, Feby Wijaya Pratiwi, Bi-Chang Chen, Peilin Chen*,* Si-Han Wu,* Chung-Yuan Mou* "Simultaneous Single-particle Tracking and Dynamic pH Sensing Reveal Lysosome-targetable Mesoporous Silica Nanoparticles Pathways", ACS Applied Materials & Interfaces, 2020, 12, 42472.
• Yi-Ping Chen, Chien-Tsu Chen,Tsang-Pai Liu, Fan-Ching Chien, Si-Han Wu*, Peilin Chen*, Chung-Yuan Mou* "Catcher in the rel: Nanoparticles-antibody conjugate as NF-κB nuclear translocation blocker" Biomaterials. 2020, 246, 119997.
• Li-An Chu, et.al., "Rapid single-wavelength lightsheet localization microscopy for clarified tissue" Nature Communications, 2019, 10, 4762.
• Chieh-Han Lu, Wei-Chun Tang, Yen-Ting Liu,Shu-Wei Chang, Frances Camille M. Wu, Chin-Yi Chen, Yun-Chi Tsai, Shun-Min Yang, Chiung- Wen Kuo, Yasushi Okada, Yeu-Kuang Hwu, Peilin Chen*, & Bi-Chang Chen,*"Lightsheet localization microscopy enables fast, large-scale, and three-dimensional super-resolution imaging" Communications Biology, 2019, 2, 177.
• Tony WH Tang ,et. al.,"Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair" Circulation, 2019, 136, 647.
• Chiung Wen Kuo, Di-Yen Chuch, Peilin Chen*, "Real-Time in vivo Imaging of Subpopulations of Circulating Tumor Cells Using Antibody Conjugated Quantum Dots" J. Nanobiotech, 2019, 17, 26.
• Po-Kai Chuang, et al.,"Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer" Proc Natl Acad Sci USA 2019, 116, 3518-3523.

• Zih-An Chen, Cheng-Hsun Wu, Si-Han Wu, * Chiung-Yin Huang, Chung-Yuan Mou, Kuo-Chen Wei, Yun Yen, I-Ting Chien, Sabiha Runa, Yi-Ping Chen, * Peilin Chen* “Receptor Ligand-Free Mesoporous Silica Nanoparticles: Streamlined Strategy for Targeted Drug Delivery Across the Blood-Brain Barrier” ACS Nano 2024, 18, 12716
• Xuejiao Tian, Tzu-Yang Lin, Po-Ting Lin, Min-Ju Tsai, Hsin Chen, Wen-Jie Chen, Chia-Ming Lee, Chiao-Hui Tu, Jui-Cheng Hsu, Tung-Han Hsieh, Yi-Chung Tung, Chien-Kai Wang, Suewei Lin, Li-An Chu, Fan-Gang Tseng, Yi-Ping Hsueh, Chi-Hon Lee, Peilin Chen & Bi-Chang Chen "Rapid lightsheet fluorescence imaging of whole Drosophila brains at nanoscale resolution by potassium acrylate-based expansion microscopy" Nature Comm. 2024, 15, 10911
• Yu-Tse Lee, Si-Han Wu, Cheng-Hsun Wu, Yu-Han Lin, Cong-Kai Lin, Zih-An Chen,Ting-Chung Sun, Yin-Ju Chen, Peilin Chen, Chung-Yuan Mou, and Yi-Ping Chen* "Drug-Free Mesoporous Silica Nanoparticles Enable Suppression of Cancer Metastasis and Confer Survival Advantages to Mice with Tumor Xenografts" ACS Appl. Mater. Interfaces 2024, 16, 61787
• Chi-Shan Li, et al., "Cytosolic galectin-4 enchains bacteria, restricts their motility and promotes inflammasome activation in intestinal epithelial cells "Proc. Natl. Acad. Sci. U.S.A., 2023, 12, e2207091120
• Yuan-Yuan Cheng, et al., "Metabolic changes associated with cardiomyocyte dedifferentiation enable adult mammalian cardiac regeneration." Circulation, 2022, 146, 1950.