陳培菱
研究員
peilingate.sinica.edu.tw
02-2787-3135
ID
E-2728-2010
陳培菱
研究員
Research Interests
- Advanced imaging: super-resolution, single molecules, intravital
- Bioelectronic and biomedical devices
- Multifunctional materials for Nanomedicine
Education
- Department of Chemistry, National Taiwan University, B.S., 1990
- Department of Chemistry, University of California, Irvine. Ph.D. 1998
Positions and Career
- Research Fellow, RCAS, Academia Sinica, 2010-present
- Chief Executive Officer, Thematic Center for Biomedical Applications, RCAS, 2023-present
- Joint Research Fellow, Institute of Physics, Academia Sinica, 2021-present
- Visiting Professor, Kyoto University, Kyoto, Japan, 2015
- Visiting Professor, RIKEN, Wako, Japan, 2012
- Chief Executive Officer, Thematic Center for Optoelectronic, RCAS, 2012
- Deputy Director, RCAS, Academia Sinica (2010 -2012)
- Associate Research Fellow, RCAS, Academia Sinica (2005-2010)
- Assistant Research Fellow, RCAS, Academia Sinica (2001-2005)
- Postdoctoral Fellow, University of California, Berkeley (1999-2001)
- Postdoctoral Fellow, University of California, Irvine (1998)
Honors and Awards
- Research Award for Junior Research Investigators, Academia Sinica, Taiwan (2007)
- Ta-You Wu Memorial Award, National Research Council, Taiwan (2007)
- Career Development Award, Academia Sinica, Taiwan (2009)
- Fellow, the Royal Society of Chemistry (2019)
- Investigator Award, Academia Sinica, Taiwan (2021)
Selected Publications
- Zih-An Chen, Cheng-Hsun Wu, Si-Han Wu, * Chiung-Yin Huang, Chung-Yuan Mou, Kuo-Chen Wei, Yun Yen, I-Ting Chien, Sabiha Runa, Yi-Ping Chen,* Peilin Chen* "Receptor Ligand-Free Mesoporous Silica Nanoparticles: Streamlined Strategy for Targeted Drug Delivery Across the Blood-Brain Barrier" ACS Nano, 2024, 18, 12716.
- Chi-Shan Li, et al., "Cytosolic galectin-4 enchains bacteria, restricts their motility and promotes inflammasome activation in intestinal epithelial cells "Proc. Natl. Acad. Sci. U.S.A., 2023, 12, e2207091120.
- Yuan-Yuan Cheng, et al., "Metabolic changes associated with cardiomyocyte dedifferentiation enable adult mammalian cardiac regeneration." Circulation, 2022, 146, 1950.
- Wei-Chun Tang, Yen-Ting Liu, Cheng-Han Yeh, Chieh-Han Lu, Chiao-Hui Tu, Yi-Ling Lin, Yu-Chun Lin, Tsui-Ling Hsu, Liang Gao, Shu-Wei Chang, Peilin Chen* and Bi-Chang Chen* "Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy" Communications Biology, 2022, 5, 879.
- Chiung Wen Kuo, Feby Wijaya Pratiwi, Yen-Ting Liu, Di-Yen Chueh and Peilin Chen* "Revealing the nanometric structural changes in myocardial infarction models by time-lapse intravital imaging" Frontiers in Bioengineering and Biotechnology, 2022, 10, 935415.
- San-Shan Huang, et al., "Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer" Science Advances, 2021, 7, eabf2400.
- Hung-Lin Chen, et.al., "Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis" (20201) J. Clin. Invest. 131, e130704.
- Rong-Lin Chang, Feby Wijaya Pratiwi, Bi-Chang Chen, Peilin Chen*,* Si-Han Wu,* Chung-Yuan Mou* "Simultaneous Single-particle Tracking and Dynamic pH Sensing Reveal Lysosome-targetable Mesoporous Silica Nanoparticles Pathways", ACS Applied Materials & Interfaces, 2020, 12, 42472.
- Yi-Ping Chen, Chien-Tsu Chen,Tsang-Pai Liu, Fan-Ching Chien, Si-Han Wu*, Peilin Chen*, Chung-Yuan Mou* "Catcher in the rel: Nanoparticles-antibody conjugate as NF-κB nuclear translocation blocker" Biomaterials. 2020, 246, 119997.
- Li-An Chu, et.al., "Rapid single-wavelength lightsheet localization microscopy for clarified tissue" Nature Communications, 2019, 10, 4762.
- Chieh-Han Lu, Wei-Chun Tang, Yen-Ting Liu,Shu-Wei Chang, Frances Camille M. Wu, Chin-Yi Chen, Yun-Chi Tsai, Shun-Min Yang, Chiung- Wen Kuo, Yasushi Okada, Yeu-Kuang Hwu, Peilin Chen*, & Bi-Chang Chen,*"Lightsheet localization microscopy enables fast, large-scale, and three-dimensional super-resolution imaging" Communications Biology, 2019, 2, 177.
- Tony WH Tang ,et. al.,"Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair" Circulation, 2019, 136, 647.
- Chiung Wen Kuo, Di-Yen Chuch, Peilin Chen*, "Real-Time in vivo Imaging of Subpopulations of Circulating Tumor Cells Using Antibody Conjugated Quantum Dots" J. Nanobiotech, 2019, 17, 26.
- Po-Kai Chuang, et al.,"Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer" Proc Natl Acad Sci USA 2019, 116, 3518-3523.