Narrative CV

Dr. Peilin Chen is a Research Fellow specializing in the development of biomaterials and bioimaging. His research interests focus on the field of nanomedicine, specifically the interactions between nanoparticles and tumors. His group has developed various nanoparticles and imaging tools to understand how nanoparticles reach and accumulate in tumors. Dr. Chen obtained his Ph.D. degree in Chemistry from the University of California, Irvine. Over the past few years, he has been invited to deliver more than 70 lectures, including plenary and keynote speeches, at international conferences. Additionally, Dr. Chen has organized over 20 international conferences and symposia.

The real-time two-photon intravital imaging tools developed by Dr. Chen's group are highly appreciated in the field. They help several medical doctors understand the disease mechanism in animal models and also benefit from the optimization of drug delivery efficiency through quantitative analysis of drug carrier distribution in various disease models.

In the past few years, Dr. Chen has coordinated more than four multidisciplinary projects. To promote the field of nanomedicine, Dr. Chen co-founded the Taiwan Nanomedicine Society and served as the executive supervisor. Regarding the commercialization of nanotechnology, Dr. Chen serves as Vice President of the Taiwan Nanotechnology Industry Development Association and an executive member of the Asia Nano Forum located in Singapore. As a mentor, Dr. Chen has guided 10 graduate students, fostering new talent in nanotechnology.

Education

• Department of Chemistry, National Taiwan University, B.S., 1990
• Department of Chemistry, University of California, Irvine. Ph.D. 1998

Positions and Career

• Research Fellow, RCAS, Academia Sinica, 2010-present
• Vice President, Taiwan Nanotechnology Industry Development Association, 2024-
• Chief Executive Officer, Thematic Center for Biomedical Applications, RCAS, 2023-2024
• Joint Research Fellow, Institute of Physics, Academia Sinica, 2021-present
• Visiting Professor, Kyoto University, Kyoto, Japan, 2015
• Visiting Professor, RIKEN, Wako, Japan, 2012
• Chief Executive Officer, Thematic Center for Optoelectronic, RCAS, 2012
• Deputy Director, RCAS, Academia Sinica (2010 -2012)
• Associate Research Fellow, RCAS, Academia Sinica (2005-2010)
• Assistant Research Fellow, RCAS, Academia Sinica (2001-2005)
• Postdoctoral Fellow, University of California, Berkeley (1999-2001)
• Postdoctoral Fellow, University of California, Irvine (1998)

Honors and Awards

• Research Award for Junior Research Investigators, Academia Sinica, Taiwan (2007)
• Ta-You Wu Memorial Award, National Research Council, Taiwan (2007)
• Career Development Award, Academia Sinica, Taiwan (2009)
• Fellow, the Royal Society of Chemistry (2019)
• Investigator Award, Academia Sinica, Taiwan (2021)

Selected Publications

• Zih-An Chen, Cheng-Hsun Wu, Si-Han Wu, * Chiung-Yin Huang, Chung-Yuan Mou, Kuo-Chen Wei, Yun Yen, I-Ting Chien, Sabiha Runa, Yi-Ping Chen,* Peilin Chen* "Receptor Ligand-Free Mesoporous Silica Nanoparticles: Streamlined Strategy for Targeted Drug Delivery Across the Blood-Brain Barrier" ACS Nano, 2024, 18, 12716.
• Chi-Shan Li, et al., "Cytosolic galectin-4 enchains bacteria, restricts their motility and promotes inflammasome activation in intestinal epithelial cells "Proc. Natl. Acad. Sci. U.S.A., 2023, 12, e2207091120.
• Yuan-Yuan Cheng, et al., "Metabolic changes associated with cardiomyocyte dedifferentiation enable adult mammalian cardiac regeneration." Circulation, 2022, 146, 1950.
• Wei-Chun Tang, Yen-Ting Liu, Cheng-Han Yeh, Chieh-Han Lu, Chiao-Hui Tu, Yi-Ling Lin, Yu-Chun Lin, Tsui-Ling Hsu, Liang Gao, Shu-Wei Chang, Peilin Chen* and Bi-Chang Chen* "Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy" Communications Biology, 2022, 5, 879.
• Chiung Wen Kuo, Feby Wijaya Pratiwi, Yen-Ting Liu, Di-Yen Chueh and Peilin Chen* "Revealing the nanometric structural changes in myocardial infarction models by time-lapse intravital imaging" Frontiers in Bioengineering and Biotechnology, 2022, 10, 935415.
• San-Shan Huang, et al., "Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer" Science Advances, 2021, 7, eabf2400.
• Hung-Lin Chen, et.al., "Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis" (20201) J. Clin. Invest. 131, e130704.
• Rong-Lin Chang, Feby Wijaya Pratiwi, Bi-Chang Chen, Peilin Chen*,* Si-Han Wu,* Chung-Yuan Mou* "Simultaneous Single-particle Tracking and Dynamic pH Sensing Reveal Lysosome-targetable Mesoporous Silica Nanoparticles Pathways", ACS Applied Materials & Interfaces, 2020, 12, 42472.
• Yi-Ping Chen, Chien-Tsu Chen,Tsang-Pai Liu, Fan-Ching Chien, Si-Han Wu*, Peilin Chen*, Chung-Yuan Mou* "Catcher in the rel: Nanoparticles-antibody conjugate as NF-κB nuclear translocation blocker" Biomaterials. 2020, 246, 119997.
• Li-An Chu, et.al., "Rapid single-wavelength lightsheet localization microscopy for clarified tissue" Nature Communications, 2019, 10, 4762.
• Chieh-Han Lu, Wei-Chun Tang, Yen-Ting Liu,Shu-Wei Chang, Frances Camille M. Wu, Chin-Yi Chen, Yun-Chi Tsai, Shun-Min Yang, Chiung- Wen Kuo, Yasushi Okada, Yeu-Kuang Hwu, Peilin Chen*, & Bi-Chang Chen,*"Lightsheet localization microscopy enables fast, large-scale, and three-dimensional super-resolution imaging" Communications Biology, 2019, 2, 177.
• Tony WH Tang ,et. al.,"Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair" Circulation, 2019, 136, 647.
• Chiung Wen Kuo, Di-Yen Chuch, Peilin Chen*, "Real-Time in vivo Imaging of Subpopulations of Circulating Tumor Cells Using Antibody Conjugated Quantum Dots" J. Nanobiotech, 2019, 17, 26.
• Po-Kai Chuang, et al.,"Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer" Proc Natl Acad Sci USA 2019, 116, 3518-3523.

• Zih-An Chen, Cheng-Hsun Wu, Si-Han Wu, * Chiung-Yin Huang, Chung-Yuan Mou, Kuo-Chen Wei, Yun Yen, I-Ting Chien, Sabiha Runa, Yi-Ping Chen, * Peilin Chen* “Receptor Ligand-Free Mesoporous Silica Nanoparticles: Streamlined Strategy for Targeted Drug Delivery Across the Blood-Brain Barrier” ACS Nano 2024, 18, 12716
• Xuejiao Tian, Tzu-Yang Lin, Po-Ting Lin, Min-Ju Tsai, Hsin Chen, Wen-Jie Chen, Chia-Ming Lee, Chiao-Hui Tu, Jui-Cheng Hsu, Tung-Han Hsieh, Yi-Chung Tung, Chien-Kai Wang, Suewei Lin, Li-An Chu, Fan-Gang Tseng, Yi-Ping Hsueh, Chi-Hon Lee, Peilin Chen & Bi-Chang Chen "Rapid lightsheet fluorescence imaging of whole Drosophila brains at nanoscale resolution by potassium acrylate-based expansion microscopy" Nature Comm. 2024, 15, 10911
• Yu-Tse Lee, Si-Han Wu, Cheng-Hsun Wu, Yu-Han Lin, Cong-Kai Lin, Zih-An Chen,Ting-Chung Sun, Yin-Ju Chen, Peilin Chen, Chung-Yuan Mou, and Yi-Ping Chen* "Drug-Free Mesoporous Silica Nanoparticles Enable Suppression of Cancer Metastasis and Confer Survival Advantages to Mice with Tumor Xenografts" ACS Appl. Mater. Interfaces 2024, 16, 61787
• Chi-Shan Li, et al., "Cytosolic galectin-4 enchains bacteria, restricts their motility and promotes inflammasome activation in intestinal epithelial cells "Proc. Natl. Acad. Sci. U.S.A., 2023, 12, e2207091120
• Yuan-Yuan Cheng, et al., "Metabolic changes associated with cardiomyocyte dedifferentiation enable adult mammalian cardiac regeneration." Circulation, 2022, 146, 1950.