Narrative CV

在博士班期間，鄭郅言博士建造了一套光學參量振盪器(OPO)雷射，以及一套自動化資料擷取系統，用來研究DNA嵌合 (chelating) 分子的振動光譜。在博士後研究期間，他整合了微流體技術與自動化系統，成功建構出一套可以同時合成1,536通道的寡核苷酸 (oligonucleotide) 合成儀。

在建立個人實驗室後，鄭博士及其團隊運用了雷射微加工技術，開發各種微流體裝置，應用於生物研究。生物研究。他們的實驗室已開發出可用於培養細胞(包括哺乳類動物細胞株與幹細胞)及生物體(如斑馬魚與珊瑚叢片段)的裝置。這些裝置使得研究人員能夠對培養中的細胞施加長期(可達數週)物理性刺激，例如電場、溫度變化與光刺激。

斑馬魚裝置能提供固定魚體並且長期培養，並可進行細胞層級的觀察，協助合作的生物實驗室進行傷口癒合研究，解開斑馬魚再生能力之謎。珊瑚晶片則協助另一個生物實驗室挑選具耐溫性的珊瑚品系，應用於珊瑚礁復育。

鄭博士的團隊成功取得大量細胞影像與光譜資料，用於人工智慧分析。近期，他們已成功應用AI進行無標記細胞存活率的定量分析。未來，他們將進一步整合AI程序控制與實驗室自動化技術，發展出適合單一實驗室的自動化細胞繼代培養系統。

Education

• Ph.D. Chemistry Department, National Taiwan University, TAIWAN, 1998
• M.S. Chemistry Department, National Taiwan University, TAIWAN, 1992
• B.S. Chemistry Department, National Taiwan University, TAIWAN, 1990

Positions and Career

• 中央研究院應用科學研究中心副主任 (2023-2025)
• 中央研究院應用科學研究生醫應用專題中心執行長 (2021-2022)
• 中央研究院應用科學研究中心力學專題中心執行長 (2015-2020)
• 中央研究院應用科學研究中心 研究員 (2013- )
• 中央研究院應用科學研究中心 副研究員 (2007-2013)
• 中央研究院應用科學工程所籌備處 助研究員 (2001-2007)
• 中央研究院生物醫學研究所 博士後研究員 (1998-2001)
• 國立海洋大學合聘 (2006- )
• 國立陽明大學合聘 (2007- )
• 長庚大學工學院合聘 (2017- )

Selected Publications

• Lai, Y.T., Wei, P.K., Kuo, C.Y. and Cheng, J.Y. (2023) Inference detection and classification of illicit drugs by a modest Raman spectrometer with a convolutional neural network analyzer. Sensor Actuat B-Chem , 375. ARTN 132923 10.1016/j.snb.2022.132923.
• Belkin, S. and Cheng, J.Y. (2023) Miniaturized bioluminescent wholecell sensor systems. Current Opinion in Biotechnology , 82. ARTN 102952 10.1016/j.copbio.2023.102952.
• Huang, W.-C., Wei, C.-D., Belkin, S., Hsieh, T.-H. and Cheng, J.-Y. (2022) Machine-learning assisted antibiotic detection and categorization using a bacterial sensor array. Sensors and Actuators B: Chemical, 355, 131257.
• Chien, T.Y., Marin-Benavides, R., Belkin, S. and Cheng, J.Y. (2022) Rapid printing of a Bacterial array for a Solid-Phase Assay (BacSPA) of heavy metal ions. Sensor Actuat B-Chem, 359.
• Chou, S.E., Lee, K.L., Wei, P.K. and Cheng, J.Y. (2021) Screening antimetastasis drugs by cell adhesion-induced color change in a biochip. Lab Chip, 21, 2955-2970.
• Chang, H.F., Chou, S.E. and Cheng, J.Y. (2021) Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices. Jove-J Vis Exp.
• Yeung, W.K., Li, H.-F., Chung, C.-L., Lee, K.-L., Wei, P.-K., Lin, H., Chen, H.-H. and Cheng, J.-Y. (2020) Promising urinary miRNA biomarkers t-SPR profiling for urothelial cell carcinoma. Sensors and Actuators B: Chemical, 322, 128605.
• Tsai, H.-F., Tsai, Y.-C., Yagur-Kroll, S., Palevsky, N., Belkin, S. and Cheng, J.-Y. (2015) Water pollutant monitoring by a whole cell array through lens-free detection on CCD. Lab Chip, 15, 1472-1480.
• Wang, C.-C., Ka, Y.-C., Chi, P.-Y., Huang, C.-W., Lin, J.-Y., Chou, C.-F., Cheng, J.-Y. and Lee, C.-H. (2011) Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip. Lab Chip, 11, 695-699.
• Hsu, T.-H., Yen, M.-H., Liao, W.-Y., Cheng, J.-Y. and Lee, C.-H. (2009) Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip. Lab Chip, 9, 884-890.
• Cheng, J.-Y., Yen, M.-H., Kuo, C.-T. and Young, T.-H. (2008) A transparent cell culture microchamber with variably controlled concentration gradient generator and flow field rectifier. Biomicrofluidics, 2, 024105.
• Wei, C.-W., Cheng, J.-Y., Huang, C.-T., Yen, M.-H. and Young, T.-H. (2005) Using a microfluidic device for 1 microliter DNA microarray hybridization in 500 seconds. Nucleic Acids Research Methods, 33, e78.

• Lai, Y.T., Wei, P.K., Kuo, C.Y. and Cheng, J.Y. (2023) Inference detection and classification of illicit drugs by a modest Raman spectrometer with a convolutional neural network analyzer. Sensor Actuat B-Chem, 375. ARTN 132923 10.1016/j.snb.2022.132923.
• Belkin, S. and Cheng, J.Y. (2023) Miniaturized bioluminescent whole-cell sensor systems. Current Opinion in Biotechnology, 82. ARTN 102952 10.1016/j.copbio.2023.102952.
• Huang, W.-C., Wei, C.-D., Belkin, S., Hsieh, T.-H. and Cheng, J.-Y. (2022) Machine-learning assisted antibiotic detection and categorization using a bacterial sensor array. Sensors and Actuators B: Chemical, 355, 131257.
• Chien, T.Y., Marin-Benavides, R., Belkin, S. and Cheng, J.Y. (2022) Rapid printing of a Bacterial array for a Solid-Phase Assay (BacSPA) of heavy metal ions. Sensor Actuat B-Chem, 359.
• Chou, S.E., Lee, K.L., Wei, P.K. and Cheng, J.Y. (2021) Screening anti-metastasis drugs by cell adhesion-induced color change in a biochip. Lab Chip, 21, 2955-2970.