Narrative CV

李超煌博士於1997年自台灣大學電機工程學研究所獲得博士學位後，在中央研究院原子與分子科學研究所進行2年博士後研究，並於2000年加入中央研究院應用科學研究中心擔任助研究員，2010年升等為研究員。他的研究領域包括光學顯微技術、細胞與微環境的交互作用，以及微流道元件在生物醫學上的應用等。

在光學顯微技術方面，李博士是「差動共焦顯微術」和「非干涉式廣視野光學測繪術」等光學奈米級量測技術的主要發明人。自2008年起，他開始利用微流道元件來控制細胞微環境，並與臨床醫師合作，研究癌細胞在微環境參數改變下的運動行為變化，並證實癌細胞與纖維母細胞之間的旁分泌迴圈。最近，李博士的團隊開發了3D細胞培養平台，進行合併不同藥物的治療法對癌細胞抗藥性影響的測試，並同時進行神經細胞在3D培養環境中的分化和再生研究。

自2004年起，李超煌博士便合聘於陽明交通大學生醫光電研究所，並於2011年至2014年擔任該所所長，持續授課並指導研究生。除此之外，李博士長期與生物學及醫學領域的專家合作，積累了豐富的跨領域研究經驗。自2016年起，他擔任中央研究院學術諮詢總會的副執行秘書，負責數理科學組的研究計畫、經費管理、研究人員聘任與升等審查等學術行政事務。自2024年起，李博士擔任新成立的關鍵議題研究中心的首位主任。

李博士將繼續探討癌細胞在3D環境中的運動行為，以及它們對多種藥物與療法的反應。他還將關注神經細胞在外部刺激下的再生潛力。除了研究，他也致力於發展關鍵議題研究中心的硬體設施和人力資源，並推動符合中央研究院政策目標的任務導向型計畫。

Education

• 1993-1997 Ph.D. in Electrical Engineering, National Taiwan University.
• 1992-1993 M.S. student in Graduate Institute of Electro-Optical Engineering, National Taiwan University.
• 1988-1992 B.S. in Electrical Engineering, National Taiwan University.
• 1985-1988 Taipei Municipal Chien Kuo Senior High School.

Positions and Career

• 中央研究院關鍵議題研究中心主任 (2024–Present)
• 中央研究院學術諮詢總會副執行秘書(2016–Present)
• 中央研究院應用科學研究中心副主任 (2014–2016)
• 國立陽明大學生醫光電研究所所長 (2011–2014)
• 國立陽明大學生醫光電研究所合聘教授 (2011–Present)
• 中央研究院應用科學研究中心研究員 (2010–Present)
• 中央研究院應用科學研究中心副研究員 (2004–2010)
• 中央研究院應用科學研究中心助研究員 (2000–2004)
• 中央研究院原子與分子科學研究所博士後研究 (1997–2000)

Honors and Awards

• 2012 中央研究院年輕學者研究著作獎
• 2010 行政院國家科學委員會吳大猷先生紀念獎

Selected Publications

• H.-J. Pan, C.-W. Lee, L.-Y. Wu, H.-H. Hsu, Y.-C. Tung, W.-Y. Liao, and C.-H. Lee, "A 3D culture system for evaluating the combined effects of cisplatin and anti-fibrotic drugs on the growth and invasion of lung cancer cells co-cultured with fibroblasts," APL Bioengineering 7, 016117 (2023).
• Y.-C. Kao, G.-Y. Lin, J.-Y. Cheng, and C.-H. Lee, "Neurite growth induced by red light-caused intracellular production of reactive oxygen species through cytochrome c oxidase activation," Journal of Photochemistry & Photobiology, B: Biology 241, 112681 (2023).
• C.-W. Lee, C.-C. Kuo, C.-J. Liang, H.-J. Pan, C.-N. Shen, and C.-H. Lee, "Effects of the media conditioned by various macrophage subtypes derived from THP-1 cells on tunneling nanotube formation in pancreatic cancer cells," BMC Molecular and Cell Biology 23, 26 (2022).
• Y.-C. Kao, Z.-H. Chen, W.-Y. Wang, C.-H. Lee, and P.-L. Kuo, "Hydrostatic pressure promotes migration and filamin-A activation in fibroblasts with increased p38 phosphorylation and TGF-β production," Biochemical and Biophysical Research Communications 568, 15-22 (2021).
• H.-H. Hou, H.-J. Pan, W.-Y. Liao, C.-H. Lee, and C.-J. Yu, "Autophagy in fibroblasts induced by cigarette smoke extract promotes invasion in lung cancer cells," International Journal of Cancer 147, 2587-2596 (2020).
• Y.-C. Kao, Y.-C. Liao, P.-L. Cheng, and C.-H. Lee, "Neurite regrowth stimulation by a red-light spot focused on the neuronal cell soma following blue light-induced retraction," Scientific Reports 9, 18210 (2019).
• C.-W. Lee, Y.-L. Chiang, J.-T. Liu, Y.-X. Chen, C.-H. Lee, Y.-L. Chen, and I.-S. Hwang, "Emerging roles of air gases in lipid bilayers," Small 14, 1802133 (2018).
• Y.-C. Kao, J.-R. Jheng, H.-J. Pan, W.-Y. Liao, C.-H. Lee, and P.-L. Kuo, "Elevated hydrostatic pressure enhances the motility and enlarges the size of the lung cancer cells through aquaporin upregulation mediated by caveolin-1 and ERK1/2 signaling," Oncogene 36, 863- 874 (2017).
• C.-H. Chang, H.-H. Lee*, and C.-H. Lee, "Substrate properties modulate cell membrane roughness by way of actin filaments," Scientific Reports 7, 9068 (2017).
• C.-W. Lee, C.-C. Wang, and C.-H. Lee, "Mechanoprofiling on membranes of living cells with atomic force microscopy and optical nano-profilometry," Advances in Physics: X 2, 608-621 (2017).

• J. C. Arifin, B.‑Y. Tsai, C.‑Y. Chen, L.‑W. Chu, Y.‑L. Lin, C.‑H. Lee, A. Chiou, and Y.‑H. Ping, “Quantification of the interaction forces between dengue virus and dopamine type‑2 receptor using optical tweezers,” Virology Journal 21, 215 (2024).
• H.-J. Pan, C.-W. Lee, L.-Y. Wu, H.-H. Hsu, Y.-C. Tung, W.-Y. Liao, and C.-H. Lee, “A 3D culture system for evaluating the combined effects of cisplatin and anti-fibrotic drugs on the growth and invasion of lung cancer cells co-cultured with fibroblasts,” APL Bioengineering 7, 016117 (2023).
• TY.-C. Kao, G.-Y. Lin, J.-Y. Cheng, and C.-H. Lee, “Neurite growth induced by red light-caused intracellular production of reactive oxygen species through cytochrome c oxidase activation,” Journal of Photochemistry & Photobiology, B: Biology 241, 112681 (2023).
• C.-W. Lee, C.-C. Kuo, C.-J. Liang, H.-J. Pan, C.-N. Shen, and C.-H. Lee, “Effects of the media conditioned by various macrophage subtypes derived from THP-1 cells on tunneling nanotube formation in pancreatic cancer cells,” BMC Molecular and Cell Biology 23, 26 (2022).
• H.-H. Hou, H.-J. Pan, W.-Y. Liao, C.-H. Lee, and C.-J. Yu, “Autophagy in fibroblasts induced by cigarette smoke extract promotes invasion in lung cancer cells,” International Journal of Cancer 147, 2587-2596 (2020).