Narrative CV

林榮信教授為應用科學中心研究員。林教授於1996年至2000年於德國于利希研究院攻讀博士學位，研究領域為細胞膜蛋白的分子動力學模擬，是該領域的先驅之一。 2000年1月獲得博士學位後，於于利希研究院的馮諾曼計算研究所擔任科學研究員，同年9月轉入美國加州大學聖地亞哥分校，在霍華休斯醫學研究所擔任生物資訊學專家， 期間將研究領域拓展至計算藥物設計，是首批將蛋白質動力學應用於基於結構的藥物設計的學者之一。 2003年初，在國立臺灣大學醫學院藥學院擔任助理教授，開始其獨立研究生涯。 2006年中受延攬至中央研究院應用科學研究中心，現亦為國立臺灣大學醫學院藥學院合聘教授。

林教授的研究重點是開發用於計算藥物探索和結構生物資訊學的新穎方法，並將其應用於探索天然物分子和其他藥物的新穎候選藥物和生物分子標靶。舉一近期研究成果為例，林教授實驗室開發了基於統計力學第一原理的結合自由能計算方法，可應用於各類生物分子的交互作用，包括蛋白質、胜肽和小分子化學分子。此外，林博士實驗室致力於提升分子嵌合(molecular docking)方法預測的準確性及拓展其可應用領域。一些新穎的應用包括MEDock、SLITHER和idTarget，其中idTarget則是首次實現了在蛋白質體範圍基於分子嵌合計算的把點，可用於預測合成的化學小分子或天然物分子的作用靶點。林教授實驗室已開發深度學習演算法和其他人工智慧方法來應用於開發藥物設計的新穎計算方法。他過去與幾個團隊合作研發的新藥已獲得16項專利。兩系列針對神經退化性疾病和癌症治療的候選藥物分別於2015年和2016年在國內獲得專屬授權。其中用於治療阿茲海默症的口服小分子藥物已於2025年2月開始I期首次人體臨床試驗。

林教授自2003年回國以來，參與多個合作團隊，致力於結構生物資訊方的開發，以及多種疾病的藥物研發。 2015年至2020年擔任中央研究院應用科學研究中心生醫應用專題中心執行長，2019年至2020年擔任中央研究院生醫轉譯研究中心副主任。 2020年11月起，擔任生醫轉譯研究中心(BioTReC)副主任，2021年至2024年也曾擔任BioTReC智慧醫學專題中心執行長。

Education

• Ph.D. in Biophysics, Forschungszentrum Jülich/University of Duisburg, Germany (2000)

Positions and Career

• Chief Executive Officer of the Thematic Center for Intelligence Medicine, Biomedical Translation Research Center, Academia Sinica (2021.4 - present)
• Deputy Director, Biomedical Translation Research Center, Academia Sinica (2020.11 - present)
• Editorial Board, Chunghwa Pharmacopoeia, Ministry of Health and Welfare, (2019 - )
• Review Panel, Division of Physics, Department of Natural Sciences and Sustainable Development, Ministry of Science and Technology (2019 – 2022)
• Delegate of Division of Mathematical and Physical Sciences, General Assembly of Academia Sinica (2017-2021)
• Deputy Director, Research Center for Applied Sciences, Academia Sinica (2019.2 - 2020.10)
• Chief Executive Officer of the Thematic Center for Biomedical Applications, Research Center for Applied Sciences, Academia Sinica (2015.1 - 2020.10)
• Joint Appointment, College of Engineering Science, Chang Gung University (2015- )
• Research Fellow, Research Center for Applied Sciences, Academia Sinica (2014.7 - present)
• Joint Appointment, School of Pharmacy, College of Medicine, National Taiwan University (2006 - )
• Joint Appointment, Institute of Biomedical Sciences, Academia Sinica (2004 - )
• Assistant Professor, School of Pharmacy, College of Medicine, National Taiwan University (2003 - 2006 )
• Bioinformatics Specialist, Howard Hughes Medical Institute, University of California at San Diego, U.S.A. (2000 – 2002)
• Postdoctoral Research, John von Neuman Institute of Computing, Forschungszentrum Jülich, Germany (2000 – 2000)

Honors and Awards

• 2019 Investigator Award, Academia Sinica

Selected Publications

• Dhananjay C. Joshi, Charlie Gosse, Shu-Yu Huang and Jung-Hsin Lin*, "A curvilinear-path umbrella sampling approach to characterizing the interactions between rapamycin and three FKBP12 variants", Front. Mol. Biosci. 9: 879000 (2022) DOI: 10.3389/fmolb.2022.879000.
• Dhananjay C. Joshi and Jung-Hsin Lin*, "Delineating protein-protein curvilinear dissociation pathways and energetics with naïve multiplewalker umbrella sampling simulations", J. Comput. Chem. 40: 1652- 1663 (2019) DOI:10.1002/jcc.25821
• Yu-Hsuan Chen and Jung-Hsin Lin*, Can ligands of different functional types induce distinct dynamics in G protein-coupled receptors? Curr. Top. Med. Chem. 17: 2370-2380 (2017)
• Jung-Hsin Lin*, "Structure- and dynamics-based computational design of anticancer drugs", Biopolymers 105: 2-9 (2016)
• Nanlan Huang and Jung-Hsin Lin*, "Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation", Nucleic Acids Res. 43: 6772-6786 (2015)
• Nan-Lan Huang and Jung-Hsin Lin*, "Drug-Induced conformational population shifts in topoisomerase-DNA ternary complexes". Molecules 15: 7415-7428 (2014)
• Jhih-Bin Chen , Ting-Rong Chern , Tzu-Tang Wei , Ching-Chow Chen , Jung-Hsin Lin*, and Jim-Min Fang*. "Design and synthesis of dualaction inhibitors targeting histone deacetylases and HMG-CoA reductase for cancer treatment." J. Med. Chem. 56: 3645-3655 (2013)
• Jui-Chih Wang and Jung-Hsin Lin*, "Scoring functions for prediction of protein-ligand interactions", Curr. Pharm. Des. 19: 2174-2182 (2013)
• Jung-Hsin Lin*. "Target prediction of small molecules with information of key molecular interactions.", Curr. Top. Med. Chem. 12: 1903-1910 (2012)
• Jui-Chih Wang, Pei-Ying Chu, Chung-Ming Chen and Jung-Hsin Lin*. "idTarget: a web server for identifying proteins targets of small chemical molecules with robust scoring functions and a divide-andconquer docking approach." Nucleic Acids Res. 40: W393-W399 (2012)

• Ting-Wei Chang, Sheng-Hann Wang, Iuan-Sheau Chin, Pei-Zhen Li, Shu-Cheng Lo, Shu-Yi Hsieh, Jung-Hsin Lin*, Pei-Kun Wei*
  Biomimetic affinity sensor for ultrasensitive detection of nicotinoids. Biosensors and Bioelectronics. 239: 115630 (2023)
• Dhananjay C. Joshi, Charlie Gosse, Shu-Yu Huang and Jung-Hsin Lin*
  A curvilinear-path umbrella sampling approach to characterizing the interactions between rapamycin and three FKBP12 variants. Front. Mol. Biosci. 9: 879000 (2022)
• Dhananjay Joshi and Jung-Hsin Lin*
  Delineating protein-protein curvilinear dissociation pathways and energetics with multiple-walker umbrella sampling simulations. J. Comput. Chem. 40: 1652-1663 (2019)
• Jui-Chih Wang, Pei-Ying Chu, Chung-Ming Chen and Jung-Hsin Lin*
  idTarget: a web server for identifying proteins targets of small chemical molecules with robust scoring functions and a divide-and-conquer docking approach. Nucleic Acids Res. 40: W393-W399 (2012).
• Po-Hsien Lee, Kuei-Ling Kuo, Pei-Ying Chu, Eric M. Liu, Jung-Hsin Lin*
  SLITHER: a web server for generating contiguous conformations of substrate molecules entering into deep active sites of proteins or migrating through channels in membrane transporters. Nucleic Acids Res. 37: W559-W564 (2009)