林榮信
研究員
Jung-Hsin Lin
(Page on Web of Science)
jhlingate.sinica.edu.tw
02-2787-3143
ID
T-7390-2019
林榮信
研究員
Research Interests
- Pharmacoinformatics
- Structural biophysics
- Large-scale all-atom molecular dynamics simulations
- Computational drug discovery
Education
- Ph.D. in Biophysics, Forschungszentrum Jülich/University of Duisburg, Germany (2000)
Positions and Career
- Chief Executive Officer of the Thematic Center for Intelligence Medicine, Biomedical Translation Research Center, Academia Sinica (2021.4 - present)
- Deputy Director, Biomedical Translation Research Center, Academia Sinica (2020.11 - present)
- Editorial Board, Chunghwa Pharmacopoeia, Ministry of Health and Welfare, (2019 - )
- Review Panel, Division of Physics, Department of Natural Sciences and Sustainable Development, Ministry of Science and Technology (2019 – 2022)
- Delegate of Division of Mathematical and Physical Sciences, General Assembly of Academia Sinica (2017-2021)
- Deputy Director, Research Center for Applied Sciences, Academia Sinica (2019.2 - 2020.10)
- Chief Executive Officer of the Thematic Center for Biomedical Applications, Research Center for Applied Sciences, Academia Sinica (2015.1 - 2020.10)
- Joint Appointment, College of Engineering Science, Chang Gung University (2015- )
- Research Fellow, Research Center for Applied Sciences, Academia Sinica (2014.7 - present)
- Joint Appointment, School of Pharmacy, College of Medicine, National Taiwan University (2006 - )
- Joint Appointment, Institute of Biomedical Sciences, Academia Sinica (2004 - )
- Assistant Professor, School of Pharmacy, College of Medicine, National Taiwan University (2003 - 2006 )
- Bioinformatics Specialist, Howard Hughes Medical Institute, University of California at San Diego, U.S.A. (2000 – 2002)
- Postdoctoral Research, John von Neuman Institute of Computing, Forschungszentrum Jülich, Germany (2000 – 2000)
Honors and Awards
- 2019 Investigator Award, Academia Sinica
Selected Publications
- Dhananjay C. Joshi, Charlie Gosse, Shu-Yu Huang and Jung-Hsin Lin*, "A curvilinear-path umbrella sampling approach to characterizing the interactions between rapamycin and three FKBP12 variants", Front. Mol. Biosci. 9: 879000 (2022) DOI: 10.3389/fmolb.2022.879000.
- Dhananjay C. Joshi and Jung-Hsin Lin*, "Delineating protein-protein curvilinear dissociation pathways and energetics with naïve multiplewalker umbrella sampling simulations", J. Comput. Chem. 40: 1652- 1663 (2019) DOI:10.1002/jcc.25821
- Yu-Hsuan Chen and Jung-Hsin Lin*, Can ligands of different functional types induce distinct dynamics in G protein-coupled receptors? Curr. Top. Med. Chem. 17: 2370-2380 (2017)
- Jung-Hsin Lin*, "Structure- and dynamics-based computational design of anticancer drugs", Biopolymers 105: 2-9 (2016)
- Nanlan Huang and Jung-Hsin Lin*, "Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation", Nucleic Acids Res. 43: 6772-6786 (2015)
- Nan-Lan Huang and Jung-Hsin Lin*, "Drug-Induced conformational population shifts in topoisomerase-DNA ternary complexes". Molecules 15: 7415-7428 (2014)
- Jhih-Bin Chen , Ting-Rong Chern , Tzu-Tang Wei , Ching-Chow Chen , Jung-Hsin Lin*, and Jim-Min Fang*. "Design and synthesis of dualaction inhibitors targeting histone deacetylases and HMG-CoA reductase for cancer treatment." J. Med. Chem. 56: 3645-3655 (2013)
- Jui-Chih Wang and Jung-Hsin Lin*, "Scoring functions for prediction of protein-ligand interactions", Curr. Pharm. Des. 19: 2174-2182 (2013)
- Jung-Hsin Lin*. "Target prediction of small molecules with information of key molecular interactions.", Curr. Top. Med. Chem. 12: 1903-1910 (2012)
- Jui-Chih Wang, Pei-Ying Chu, Chung-Ming Chen and Jung-Hsin Lin*. "idTarget: a web server for identifying proteins targets of small chemical molecules with robust scoring functions and a divide-andconquer docking approach." Nucleic Acids Res. 40: W393-W399 (2012)