Narrative CV

Dr. Yu-Jung Lin received her Ph.D. degree in Physiology from National Yang-Ming University in 2014 and subsequently joined the Department of Chemical Engineering at National Tsing Hua University as a Postdoctoral Fellow. Since 2020, Dr. Lin has served as an independent Principal Investigator at the Research Center for Applied Sciences, Academia Sinica. Her research group focuses on engineering advanced drug delivery systems to reprogram pathological tissue microenvironments, aiming to improve therapeutic outcomes. Recent work has resulted in several publications in leading journals such as ACS Nano, Biomaterials, and Chemical Engineering Journal. Key achievements include a menthol-based platform for inducing adipocyte browning to treat metabolic disorders, hydrogen-generating systems to modulate inflammation, and nanoparticle systems designed to enhance cancer immunotherapy. Lin's Lab also developed electroactive dressings that accelerate wound healing process while enabling non-invasive monitoring. These research activities are supported by competitive funding, including the NSTC 2030 Cross-Generation Young Scholars Program, and have been recognized by Young Investigator Award from Prof. Chau-Jen Lee Biomedical Engineering Development Foundation. Looking ahead, Lin's team aims to explore the potential of nerve–immune interactions in tumor microenvironment remodeling, expand their research into the field of regenerative medicine, and strengthen interdisciplinary collaboration to accelerate clinical translation of research outcomes.

Education

• Ph.D. in Physiology, National Yang-Ming University, Taipei, Taiwan (2014)

Positions and Career

• Assistant Research Fellow, Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan (2020~present)
• Postdoctoral Fellow, Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan (2015~2020)
• Visiting Scholar, Department of Physiology, University of Kentucky, Lexington, KY, USA (2011~2013)

Honors and Awards

• 2022 Cross-Generation Young Scholars Program (Emerging Young Scholars), National Science and Technology Council, Taiwan
• 2020 Young Investigator Award, Prof. Chau-Jen Lee Biomedical Engineering Development Foundation, Taiwan
• 2019 Best Research Paper Award for Postdoctoral Fellows, Ministry of Science and Technology, Taiwan

Selected Publications

• Ngo, T. L. H., Wang, K. L., Pan, W. Y., Ruan, T.*, Lin, Y. J.* Immunomodulatory prodrug micelles imitate mild heat effects to reshape tumor microenvironment for enhanced cancer immunotherapy. ACS Nano 2024, 18, 5632–5646.
• Ruan, T., Fu, C. Y., Lin, C. H., Chou, K. C., Lin, Y. J.* Nanocontrollermediated dissolving hydrogel that can sustainably release coldmimetic menthol to induce adipocyte browning for treating obesity and its related metabolic disorders. Biomaterials 2023, 297, 122120.
• Wu, C. Y., Mac, C. H., Yang, T. H., Nguyen, K., Lo, S. K., Chang, Y., Lai, P. L., Sung, H. W.*, Lin, Y. J.* Nanoscale photocatalytic hydrogen production system mitigates inflammation by harnessing glycolysis waste. Chemical Engineering Journal 2023, 476, 146614.
• Chou, C. W., Chia, W. T., Mac, C. H., Wu, C. Y., Chen, C. C., Song, H. L., Lin, Y. H., Lin, Y. J.*, Sung, H. W.* Selective accumulation of ionic nanocrystal H2 storage system as an in situ H₂/boric acid nanogenerator fights against ethanol-induced gastric ulcers. Chemical Engineering Journal 2023, 463, 142373.
• Nguyen, N., Lin, Z. H., Barman, S. R. Korupalli, C., Cheng, J. Y., Song, N. X., Chang, Y., Mi, F. L., Song, H. L., Sung, H. W.*, Lin, Y. J.* Engineering an integrated electroactive dressing to accelerate wound healing and monitor noninvasively progress of healing. Nano Energy 2022, 99, 107393.
• Mac, C. H., Chan, H. Y., Lin, Y. H., Sharma, A. K., Song, H. L., Chan, Y. S., Lin, K. J.*, Lin, Y. J.*, Sung, H. W.* Engineering a biomimetic bone scaffold that can regulate redox homeostasis and promote osteogenesis to repair large bone defects. Biomaterials 2022, 286, 121574.
• Miao, Y. B.†, Lin, Y. J.†, Chen, K. H.†, Luo, P. K., Chuang, S. H., Yu, Y. T., Tai, H. M., Chen, C. T., Lin, K. J., Sung, H. W. Engineering nanoand microparticles as oral delivery vehicles to promote intestinal lymphatic drug transport. Advanced Materials 2021, 33, e2104139. (†Equal Contribution)
• Korupalli, C., Li, H., Nguyen, N., Mi, F. L., Chang, Y., Lin, Y. J.*, Sung, H. W.* Conductive materials for healing wounds: their incorporation in electroactive wound dressings, characterization, and perspectives. Advanced Healthcare Materials 2021, 10, 2001384.
• Lin, Y. J., Chen, C. C., Nguyen, D., Su, H. R., Lin, K. J., Chen, H. L., Hu, Y. J., Lai, P. L., Sung, H. W. Biomimetic engineering of a scavengerfree nitric oxide-generating/delivering system to enhance radiation therapy. Small 2020, 16, e2000655. (Selected as Inside Cover)
• Lin, Y. J., Chen, C. C., Chi, N. W., Nguyen, T., Lu, H. Y., Nguyen, D., Lai, P. L., Sung, H. W. In situ self-assembling micellar depots that can actively trap and passively release NO with long-lasting activity to reverse osteoporosis. Advanced Materials 2018, 30, e1705605.

• Ngo, T. L. H., Wang, K. L., Pan, W. Y., Ruan, T.*, Lin, Y. J.* Immunomodulatory prodrug micelles imitate mild heat effects to reshape tumor microenvironment for enhanced cancer immunotherapy. ACS Nano 2024, 18, 5632–5646.
• Ruan, T., Fu, C. Y., Lin, C. H., Chou, K. C., Lin, Y. J.* Nanocontroller-mediated dissolving hydrogel that can sustainably release cold-mimetic menthol to induce adipocyte browning for treating obesity and its related metabolic disorders. Biomaterials 2023, 297, 122120.
• Wu, C. Y., Mac, C. H., Yang, T. H., Nguyen, K., Lo, S. K., Chang, Y., Lai, P. L., Sung, H. W.*, Lin, Y. J.* Nanoscale photocatalytic hydrogen production system mitigates inflammation by harnessing glycolysis waste. Chemical Engineering Journal 2023, 476, 146614.
• Chou, C. W., Chia, W. T., Mac, C. H., Wu, C. Y., Chen, C. C., Song, H. L., Lin, Y. H., Lin, Y. J.*, Sung, H. W.* Selective accumulation of ionic nanocrystal H2 storage system as an in situ H2/boric acid nanogenerator fights against ethanol-induced gastric ulcers. Chemical Engineering Journal 2023, 463, 142373.
• Nguyen, N., Lin, Z. H., Barman, S. R. Korupalli, C., Cheng, J. Y., Song, N. X., Chang, Y., Mi, F. L., Song, H. L., Sung, H. W.*, Lin, Y. J.* Engineering an integrated electroactive dressing to accelerate wound healing and monitor noninvasively progress of healing. Nano Energy 2022, 99, 107393.