Narrative CV

Dr. Yi-Chung Tung is a Research Fellow at the Research Center for Applied Sciences, Academia Sinica, where he has been conducting interdisciplinary biomedical research since 2009. Previously, he was a postdoctoral fellow in the Department of Biomedical Engineering at the University of Michigan, Ann Arbor (2006–2009), where he also earned his Ph.D. in Mechanical Engineering in 2005. His contributions have been widely recognized with numerous prestigious awards, including the 2020–2022 Scientist with Top 2% Single Year Impact, the 2018 Project for Excellent Junior Research Investigators (Ministry of Science and Technology, Taiwan), the 2016 Career Development Award (Academia Sinica), and the 2014 Ta-You Wu Memorial Award (Ministry of Science and Technology, Taiwan). He was also named a Top 10% Highly Cited Author in the Analytical Portfolio of Royal Society of Chemistry Journals in 2016. His research focuses on microfluidic cell culture and analysis, biomedical instrumentation, and advanced micro/nano-fabrication techniques, driving innovations in biomedical technology. Dr. Tung has established domestic and international collaborations, including with Ohio State University and Boston University, to advance biomedical research. His lab is currently developing automated, intelligence-embedded instrumentation to enhance biomedical investigations, with a particular focus on cancer and neuro-related studies.

Education

• Ph. D. in Mechanical Engineering, University of Michigan, Ann Arbor (2005)
• M.S.E. in Electrical Engineering, University of Michigan, Ann Arbor (2004)
• M.S. in Mechanical Engineering, National Taiwan University (1998)
• B.S. in Mechanical Engineering, National Taiwan University (1996)

Positions and Career

• Executive Officer of Thematic Center for Intelligence Bioengineering (TCIB), Research Center for Applied Sciences, Academia Sinica (2025 - )
• Research Fellow/Professor, Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan (2018 - )
• Associate Research Fellow/Professor, Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan (2013 - 2018)
• Assistant Research Fellow/Professor, Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan (2009 - 2013)
• Postdoctoral Research Fellow, Biomedical Engineering, University of Michigan, Ann Arbor (2006 - 2009)

Honors and Awards

• 2020-2022 Scientist with Top 2% Single Year Impact
• 2018 Project for Excellent Junior Research Investigators, Taiwan Ministry of Science and Technology (MOST)
• 2016 Career Development Award, Academia Sinica
• 2016 Top 10% Highly Cited Author, Analytical Portfolio of Royal Society of Chemistry (RSC) Journals
• 2014 Ta-You Wu Memorial Award, Taiwan Ministry of Science and Technology (MOST)

Selected Publications

• D.-M. Chang, H.-H. Hsu, P.-L. Ko, T.-H. Hsieh, H.-M. Wu*, and Y.-C. Tung*, "Rapid Time-Lapse 3D Oxygen Tension Measurement within Hydrogels Using Widefield Frequency Domain Fluorescence Lifetime Imaging Microscopy (FD-FLIM) and Image Segmentation," Analyst, Vol. 149, Issue 6, pp. 727-1737, March 2024. (Featured as the back cover image)
• H.-H. Hsu, P.-L. Ko, C.-C. Peng, Y.-J. Cheng, H.-M. Wu, and Y.-C. Tung*, "Studying Sprouting Angiogenesis under Combination of Oxygen Gradients and Co-Culture of Fibroblasts Using Microfluidic Cell Culture Model," Materials Today Bio, Vol. 21, 100703, August 2023.
• C.-W. Chang, H.-C. Shih, M. Cortes-Medina, P. E. Beshay, A. Avendano, A. J. Seibel, W.-H. Liao, Y-C. Tung*, and J. W. Song*, "ECM-Derived Biophysical Cues Mediate Interstitial Flow-Induced Sprouting Angiogenesis," ACS Applied Materials & Interfaces, Vol. 15, pp. 15047-15088, March 2023.
• P.-L. Ko, C.-K. Wang, H.-H. Hsu, T.-A. Lee, and Y.-C. Tung*, "Revealing Anisotropic Elasticity of Endothelium under Fluid Shear Stress," Acta Biomaterialia, Vol. 145, pp. 316-328, June 2022.
• Y.-C. Tung, C.-K. Wang, Y.-K. Huang, C.-K. Huang, C.-C. Peng, B. Patra, H.-K. Chen, P.-N. Tsao*, and T.-Y. Ling*, "Identifying Distinct Oxygen Diffusivity through Type I Pneumocyte-Like Cell Layers Using Microfluidic Device," Talanta, Vol. 236, 122882, January 2022.
• Y.-C. Chen, J.-J. Chen, Y.-J. Hsiao, C.-Z. Xie, C.-C. Peng, Y.-C. Tung*, and Y.-F. Chen*, "Plasmonic Gel Films for Time-Lapse LSPR Detection of Hydrogen Peroxide Secreted from Living Cells," Sensors and Actuators B: Chemical, Vol. 336, 129725, June 2021.
• H.-H. Hsu, P.-L. Ko, H.-M. Wu, H.-C. Line, C.-K. Wang, and Y.-C. Tung*, "Study Formation of Three-Dimensional Endothelial Cell Network under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside-Down Microfluidic Device," Small, Vol. 17, Issue 15, 2006091, April 2021. (Featured as the inside back cover image)
• H.-C. Shih, T.-A. Lee, H.-M. Wu, P.-L. Ko, W.-H. Liao, and Y.-C. Tung*, "Microfluidic Collective Cell Migration Assay for Study of Endothelial Cell Proliferation and Migration under Combinations of Oxygen Gradients, Tensions, and Drug Treatments," Scientific Reports, Vol. 9, 8234, June 2019.
• H.-M. Wu, T.-A. Lee, P.-L. Ko, W.-H. Liao, T.-H. Hsieh, and Y.-C. Tung*, "Widefield Frequency Domain Fluorescence Lifetime Imaging Microscopy (FD-FLIM) for Accurate Measurement of Oxygen Gradients within Microfluidic Devices," Analyst, Vol. 144, Issue 11, pp. 3494-3504, June 2019. (Featured as the inside back cover image)

• Y.-H. Liu, M.-T. Chung, H.-C. Lin, T.-A. Lee, Y.-J. Cheng, C.-C. Huang, H.-M. Wu*, and Y.-C. Tung*, “Shaping Early Neural Development by Timed Elevated Tissue Oxygen Tension: Insights from Multiomic Analysis on Human Cerebral Organoids,” Science Advances, Vol. 11, ado1164, March 2025.
• H.-H. Hsu, P.-L. Ko, C.-C. Peng, Y.-J. Cheng, H.-M. Wu, and Y.-C. Tung*, “Studying Sprouting Angiogenesis under Combination of Oxygen Gradients and Co-Culture of Fibroblasts Using Microfluidic Cell Culture Model,” Materials Today Bio, Vol. 21, 100703, August 2023.
• C.-W. Chang, H.-C. Shih, M. Cortes-Medina, P. E. Beshay, A. Avendano, A. J. Seibel, W.-H. Liao, Y.-C. Tung*, and J. W. Song*, “ECM-Derived Biophysical Cues Mediate Interstitial Flow-Induced Sprouting Angiogenesis,” ACS Applied Materials & Interfaces, Vol. 15, pp. 15047-15088, March 2023.
• P.-L. Ko, C.-K. Wang, H.-H. Hsu, T.-A. Lee, and Y.-C. Tung*, “Revealing Anisotropic Elasticity of Endothelium under Fluid Shear Stress,” Acta Biomaterialia, Vol. 145, pp. 316-328, June 2022.
• H.-H. Hsu, P.-L. Ko, H.-M. Wu, H.-C. Line, C.-K. Wang, and Y.-C. Tung*, “Study Formation of Three-Dimensional Endothelial Cell Network under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside-Down Microfluidic Device,” Small, Vol. 17, Issue 15, 2006091, April 2021. (Featured as the inside back cover image)