Narrative CV

魏培坤教授現任中央研究院應用科學研究中心(RCAS)主任兼研究員,專長於奈米光子學在生物感測應用上的研究。目前，他的研究重點包括數位奈米電漿技術、低成本生物感測晶片及高通量篩選(HTS)成像技術。魏教授於1994年獲得國立台灣大學電機工程博士學位，專攻積體光學，隨後在中央研究院原子與分子科學研究所(IAMS, AS)從事近場光學領域的博士後研究。自2000年加入應用科學研究中心(RCAS, AS)以來，魏教授致力於研究奈米科學與工程技術。

魏教授在積體光學、近場光學、奈米光子學與生物感測相關領域發表超過180篇國際期刊論文，並取得12項專利，其中3項技術已成功技轉。他所開發的創新生物感測晶片與成像技術榮獲2024年國家新創獎,並正與公司合作開發。

魏教授的奈米光子感測技術與多家國內外研究機構合作開發，合作機構包括東京大學機械工程系(光纖式感測技術)、北海道大學(RIES,奈米結構感測晶片)、國立台灣大學應用力學研究所(PCR產物檢測)、以及中央研究院物理研究所(高通量篩選(HTS)技術應用於生物分子交互作用研究)。此外，作為導師，魏教授指導來自合作機構的研究生，培育奈米製程、光子元件與生物感測領域的新興人才。在學術服務方面，魏教授近年來擔任中央研究院關鍵議題中心(RCCI, AS)學術諮詢委員，並於2024年擔任OPTIC Taiwan會議主席，還是國科會矽光子計畫(NSTC)審查委員。

未來，魏教授的研究目標是將生物感測晶片與高通量篩選(HTS)成像技術推向實際應用，並聚焦於農藥殘留、環境荷爾蒙及感染性病毒的檢測，為公共衛生與環境監測提供先進解決方案。

Education

• 1989 Bachelor in Mechanical Engineering, National Taiwan University, Taiwan
• 1994 Doctor of Philosophy (Ph.D.) in Electrical Engineering, National Taiwan University

Positions and Career

• Director, Research Center for Applied Sciences, Academia Sinica (2023 – )
• Adjunct Professor, Institute of Applied Mechanics, National Taiwan University (2024 – )Acting Director, Research Center for Applied Sciences, Academia Sinica (2022 – 2023)
• Deputy Director, Research Center for Applied Sciences, Academia Sinica (2012 – 2019)
• Adjunct Professor, Department of Photonics, National Sun Yat-sen University (2015 – )
• Adjunct Professor, Institute of Biophotonics Engineering, National Yang- Ming Chia-Tung University, (2011 – )
• Acting Executive Officer of the thematic center for Mechanics and Engineering Science, Academia Sinica (2009 – 2014)
• Research Fellow, Research Center for Applied Sciences, Academia Sinica (2009 – )
• Adjunct Professor, Institute of Optoelectronic Sciences, National Taiwan Ocean University (2006 – 2021)
• Assistant Research Fellow, Institute of Applied Science and Engineering research (preparatory house), Academia Sinica (2000 – 2004)

Honors and Awards

• 2021 Presidential scholars, Academia Sinica
• 2018 Industrial paper award (Champion), International Conference on Smart Sensors
• 2017 SPIE Senior Member
• 1994 Doctoral Thesis Award, Optical Society of Taiwan

Selected Publications

• Ting-Wei Chang, Sheng-Hann Wang, Iuan-Sheau Chin, Pei- Zhen Li, Shu-Cheng Lo, Shu-Yi Hsieh, Jung-Hsin Lin*, Pei-Kuen Wei*,"Biomimetic affinity sensor for the ultrasensitive detection of neonicotinoids", Biosens. & Bioelectron. 239, (2023) 115630.
• Yi-Ting Lai, Pei-Kuen Wei, Chih-Yu Kuo, Ji-Yen Cheng, "Inference detection and classification of illicit drugs by a modest Raman spectrometer with a convolutional neural network analyzer," Sensors and Actuators B: Chemical, 375, 132923, (2023).
• Shu-cheng Lo, Chia-wei Lee, Ruey-lin Chern, and Pei-kuen Wei*, "Hybrid modes in gold nanoslit arrays on Bragg nanostructures and their application for sensitive biosensors," Opt. Express 30, 30494- 30506 (2022).
• Shu-Cheng Lo, Sheng-Hann Wang, Ting-Wei Chang, Kuang-Li Lee, Ruey-Lin Chern, and Pei-Kuen Wei*, "Dual Gold-Nanoslit Electrodes for Ultrasensitive Detection of Antigen–Antibody Reactions in Electrochemical Surface Plasmon Resonance", ACS Sensors 2022 7 (9), 2597-2605.
• Yi-Ru Li, Kuang-Li Lee, Kuan-Ming Chen, Yun Cheng Lu, Pin Chieh Wu, Sy-Hann Chen, Jiun-Haw Lee, and Pei-Kuen Wei*, "Direct detection of virus-like particles using color images of plasmonic nanostructures," Opt. Express 30, 22233-22246 (2022).
• Chia-Wen Kuo, Sheng-Hann Wang, Shu-Cheng Lo, Wei-Han Yong, Ya-Lun Ho, Jean-Jacques Delaunay, Wan-Shao Tsai, and Pei-Kuen Wei*, "Sensitive Oligonucleotide Detection Using Resonant Coupling between Fano Resonance and Image Dipoles of Gold Nanoparticles", ACS Applied Materials & Interfaces, 2022, 30:14012-14024.
• Han-Yun Hsieh, Jia-Xian Luo, Yi-Hong Shen, Shu-Cheng Lo, Yi-Chiung Hsu, Hidetoshi Tahara, Yu-Jui Fan*, Pei-Kuen Wei*, Horn-Jiunn Sheen*, "A nanofluidic preconcentrator integrated with an aluminumbased nanoplasmonic sensor for Epstein-Barr virus detection," Sensors and Actuators B: Chemical, 355, 2022, 131327.
• Sheng-Hann Wang; Chia-Wen Kuo; Shu-Cheng Lo; Wing Kiu Yeung; Ting-Wei Chang; Pei-Kuen Wei*, "Spectral Image Contrast-Based Flow Digital Nanoplasmon-metry for Ultrasensitive Antibody Detection", Journal of Nanobiotechnology. 2 20, (2022).
• Han-Yun Hsieh, Ray Chang, Yung-Yu,Huang, Po-Han,Juan, Hidetoshi Tahara, Kuan-Li Lee, Di Ngoc Kha Vo, Ming-Han Tsai, Pei-Kuen Wei*, Horn-Jiunn Sheen*, Yu-Jui Fan*, "Continuous polymerase chain reaction microfluidics integrated with a gold-capped nanoslit sensing chip for Epstein-Barr virus detection", Biosens. & Bioelectron. 2022, 195, 113672.
• Shu-Cheng Lo, Chun-Wei Yeh, Sheng-Hann Wang, Chia-Wen Kuo, Kuang-Li Lee, Ruey-Lin Chern, Pei-Kuen Wei*, "Self-Referencing Biosensors Using Fano Resonance in Periodic Aluminium Nanostructures", Nanoscale, 2021, 13, 17775-17783.

• Ting-Wei Chang, Ting-Hao Chuang, Sheng-Hann Wang, Wing Kiu Yeung*, Pei-Kuen Wei*,”Self-referenced Digital Spectral Chromatic Local Surface Plasmon Resonance in Ultrasensitive Severe Sepsis Interleukin-6 Detection”, ACS Sens. 2025, 10, 2, 1178–1186
• (Patents) Pei-Kuen Wei, Ming-Yang Pan, Kuang-Li Lee: METHOD AND APPARATUS FOR SURFACE PLASMON RESONANCE IMAGING, US Patent No.: US 12,099,009 B2, Sep. 24, 2024; European Patent No. EP3861325 04.12.2024
• Ting-Wei Chang, Sheng-Hann Wang, Iuan-Sheau Chin, Pei-Zhen Li, Shu-Cheng Lo, Shu-Yi Hsieh, Jung-Hsin Lin*, Pei-Kuen Wei*,”Biomimetic affinity sensor for the ultrasensitive detection of neonicotinoids”, Biosens. & Bioelectron. 239, 2023, 115630
• Shu-Cheng Lo, Sheng-Hann Wang, Ting-Wei Chang, Kuang-Li Lee, Ruey-Lin Chern, and Pei-Kuen Wei*, ”Dual Gold-Nanoslit Electrodes for Ultrasensitive Detection of Antigen–Antibody Reactions in Electrochemical Surface Plasmon Resonance”, ACS Sensors 2022 7 (9), 2597-2605
• Sheng-Hann Wang; Chia-Wen Kuo; Shu-Cheng Lo; Wing Kiu Yeung; Ting-Wei Chang; Pei-Kuen Wei*, “Spectral Image Contrast-Based Flow Digital Nanoplasmon-metry for Ultrasensitive Antibody Detection”, Journal of Nanobiotechnology. 2 20, (2022)

Video

複製影片連結

https://www.rcas.sinica.edu.tw/files/reshl/PeiKuenWei_2024_Biosensing.mp4