Narrative CV

Dr. Pei-Kuen Wei is the Director and Full Research Fellow at RCAS, specializing in nano-photonics for biosensing applications. His current research focuses on digital nanoplasmonics, low-cost biosensing chips, and imaging technology for high-throughput screening (HTS) applications. He earned his Ph.D. in Electrical Engineering from NTU in 1994, specializing in integrated optics, and later conducted postdoctoral research at IAMS, Academia Sinica (AS), in the field of near-field optics. Since joining RCAS (AS) in 2000, Dr. Wei has dedicated his efforts to advancing nanoscience and engineering.

Dr. Wei has published over 180 journal papers in integrated optics, near-field optics, nano-photonics, and biosensors. His research has led to 12 patents, including 3 technology transfers. His novel sensing chips and imaging technology received the National Innovation Award (2024) and are currently being developed in collaboration with a company.

Dr. Wei's nanophotonic sensors are being developed in collaboration with domestic and international institutes, including Tokyo University (Mechanical Engineering Department) for fiber-based sensors, Hokkaido University (RIES) for nanostructured sensing chips, National Taiwan University (Institute of Applied Mechanics) for PCR product detection, and Academia Sinica (Institute of Physics) for high-throughput screening (HTS) of biomolecular interactions.

As a mentor, Dr. Wei has guided numerous graduate students from partner institutions, fostering new talent in nanofabrication, photonic devices, and biosensors. Additionally, he has served as a Member of the Academic Advisory Committee (AAC) at RCCI (AS), Conference Chair of OPTIC Taiwan (2024), and Review Panelist for the Silicon Photonics Project at NSTC.

Moving forward, Dr. Wei's research aims to translate biosensing chips and HTS imaging tools into real-world applications. These technologies will be applied to the detection of pesticide residues, environmental hormones, and infectious viruses, addressing critical challenges in public health and environmental monitoring.

Education

• 1989 Bachelor in Mechanical Engineering, National Taiwan University, Taiwan
• 1994 Doctor of Philosophy (Ph.D.) in Electrical Engineering, National Taiwan University

Positions and Career

• Director, Research Center for Applied Sciences, Academia Sinica (2023 – )
• Adjunct Professor, Institute of Applied Mechanics, National Taiwan University (2024 – )Acting Director, Research Center for Applied Sciences, Academia Sinica (2022 – 2023)
• Deputy Director, Research Center for Applied Sciences, Academia Sinica (2012 – 2019)
• Adjunct Professor, Department of Photonics, National Sun Yat-sen University (2015 – )
• Adjunct Professor, Institute of Biophotonics Engineering, National Yang- Ming Chia-Tung University, (2011 – )
• Acting Executive Officer of the thematic center for Mechanics and Engineering Science, Academia Sinica (2009 – 2014)
• Research Fellow, Research Center for Applied Sciences, Academia Sinica (2009 – )
• Adjunct Professor, Institute of Optoelectronic Sciences, National Taiwan Ocean University (2006 – 2021)
• Assistant Research Fellow, Institute of Applied Science and Engineering research (preparatory house), Academia Sinica (2000 – 2004)

Honors and Awards

• 2021 Presidential scholars, Academia Sinica
• 2018 Industrial paper award (Champion), International Conference on Smart Sensors
• 2017 SPIE Senior Member
• 1994 Doctoral Thesis Award, Optical Society of Taiwan

Selected Publications

• Ting-Wei Chang, Sheng-Hann Wang, Iuan-Sheau Chin, Pei- Zhen Li, Shu-Cheng Lo, Shu-Yi Hsieh, Jung-Hsin Lin*, Pei-Kuen Wei*,"Biomimetic affinity sensor for the ultrasensitive detection of neonicotinoids", Biosens. & Bioelectron. 239, (2023) 115630.
• Yi-Ting Lai, Pei-Kuen Wei, Chih-Yu Kuo, Ji-Yen Cheng, "Inference detection and classification of illicit drugs by a modest Raman spectrometer with a convolutional neural network analyzer," Sensors and Actuators B: Chemical, 375, 132923, (2023).
• Shu-cheng Lo, Chia-wei Lee, Ruey-lin Chern, and Pei-kuen Wei*, "Hybrid modes in gold nanoslit arrays on Bragg nanostructures and their application for sensitive biosensors," Opt. Express 30, 30494- 30506 (2022).
• Shu-Cheng Lo, Sheng-Hann Wang, Ting-Wei Chang, Kuang-Li Lee, Ruey-Lin Chern, and Pei-Kuen Wei*, "Dual Gold-Nanoslit Electrodes for Ultrasensitive Detection of Antigen–Antibody Reactions in Electrochemical Surface Plasmon Resonance", ACS Sensors 2022 7 (9), 2597-2605.
• Yi-Ru Li, Kuang-Li Lee, Kuan-Ming Chen, Yun Cheng Lu, Pin Chieh Wu, Sy-Hann Chen, Jiun-Haw Lee, and Pei-Kuen Wei*, "Direct detection of virus-like particles using color images of plasmonic nanostructures," Opt. Express 30, 22233-22246 (2022).
• Chia-Wen Kuo, Sheng-Hann Wang, Shu-Cheng Lo, Wei-Han Yong, Ya-Lun Ho, Jean-Jacques Delaunay, Wan-Shao Tsai, and Pei-Kuen Wei*, "Sensitive Oligonucleotide Detection Using Resonant Coupling between Fano Resonance and Image Dipoles of Gold Nanoparticles", ACS Applied Materials & Interfaces, 2022, 30:14012-14024.
• Han-Yun Hsieh, Jia-Xian Luo, Yi-Hong Shen, Shu-Cheng Lo, Yi-Chiung Hsu, Hidetoshi Tahara, Yu-Jui Fan*, Pei-Kuen Wei*, Horn-Jiunn Sheen*, "A nanofluidic preconcentrator integrated with an aluminumbased nanoplasmonic sensor for Epstein-Barr virus detection," Sensors and Actuators B: Chemical, 355, 2022, 131327.
• Sheng-Hann Wang; Chia-Wen Kuo; Shu-Cheng Lo; Wing Kiu Yeung; Ting-Wei Chang; Pei-Kuen Wei*, "Spectral Image Contrast-Based Flow Digital Nanoplasmon-metry for Ultrasensitive Antibody Detection", Journal of Nanobiotechnology. 2 20, (2022).
• Han-Yun Hsieh, Ray Chang, Yung-Yu,Huang, Po-Han,Juan, Hidetoshi Tahara, Kuan-Li Lee, Di Ngoc Kha Vo, Ming-Han Tsai, Pei-Kuen Wei*, Horn-Jiunn Sheen*, Yu-Jui Fan*, "Continuous polymerase chain reaction microfluidics integrated with a gold-capped nanoslit sensing chip for Epstein-Barr virus detection", Biosens. & Bioelectron. 2022, 195, 113672.
• Shu-Cheng Lo, Chun-Wei Yeh, Sheng-Hann Wang, Chia-Wen Kuo, Kuang-Li Lee, Ruey-Lin Chern, Pei-Kuen Wei*, "Self-Referencing Biosensors Using Fano Resonance in Periodic Aluminium Nanostructures", Nanoscale, 2021, 13, 17775-17783.

• Ting-Wei Chang, Ting-Hao Chuang, Sheng-Hann Wang, Wing Kiu Yeung*, Pei-Kuen Wei*,”Self-referenced Digital Spectral Chromatic Local Surface Plasmon Resonance in Ultrasensitive Severe Sepsis Interleukin-6 Detection”, ACS Sens. 2025, 10, 2, 1178–1186
• (Patents) Pei-Kuen Wei, Ming-Yang Pan, Kuang-Li Lee: METHOD AND APPARATUS FOR SURFACE PLASMON RESONANCE IMAGING, US Patent No.: US 12,099,009 B2, Sep. 24, 2024; European Patent No. EP3861325 04.12.2024
• Ting-Wei Chang, Sheng-Hann Wang, Iuan-Sheau Chin, Pei-Zhen Li, Shu-Cheng Lo, Shu-Yi Hsieh, Jung-Hsin Lin*, Pei-Kuen Wei*,”Biomimetic affinity sensor for the ultrasensitive detection of neonicotinoids”, Biosens. & Bioelectron. 239, 2023, 115630
• Shu-Cheng Lo, Sheng-Hann Wang, Ting-Wei Chang, Kuang-Li Lee, Ruey-Lin Chern, and Pei-Kuen Wei*, ”Dual Gold-Nanoslit Electrodes for Ultrasensitive Detection of Antigen–Antibody Reactions in Electrochemical Surface Plasmon Resonance”, ACS Sensors 2022 7 (9), 2597-2605
• Sheng-Hann Wang; Chia-Wen Kuo; Shu-Cheng Lo; Wing Kiu Yeung; Ting-Wei Chang; Pei-Kuen Wei*, “Spectral Image Contrast-Based Flow Digital Nanoplasmon-metry for Ultrasensitive Antibody Detection”, Journal of Nanobiotechnology. 2 20, (2022)

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